We are now near the top of the mitochondrial pathway of apoptosis, at the point before the
mitochondrial outer membrane permeabilizes to release proteins such as cytochrome c into …

Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

Cell death supports morphogenesis during development and homeostasis after birth by
removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are
critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors …

BCL-2 family proteins, which have either pro-or anti-apoptotic activities, have been studied
intensively for the past decade owing to their importance in the regulation of apoptosis …

Programmed cell death is a distinct genetic and biochemical pathway essential to
metazoans. An intact death pathway is required for successful embryonic development and …

Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed
by proteases called caspases. The Bcl2 family of intracellular proteins is the central …

REVIEW Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell
suicide program critical for development, tissue homeostasis, and protection against …