The molecular origins of the mechanical properties of fibrin

MR Falvo, OV Gorkun, ST Lord - Biophysical chemistry, 2010 - Elsevier
When normal blood circulation is compromised by damage to vessel walls, clots are formed
at the site of injury. These clots prevent bleeding and support wound healing. To sustain …

Helical peptide structure improves conductivity and stability of solid electrolytes

Y Chen, T Xue, C Chen, S Jang, PV Braun, J Cheng… - Nature materials, 2024 - nature.com
Ion transport is essential to energy storage, cellular signalling and desalination. Polymers
have been explored for decades as solid-state electrolytes by either adding salt to polar …

The dynamics of γ-secretase and its substrates

M Hitzenberger, A Götz, S Menig… - Seminars in cell & …, 2020 - Elsevier
Abstract γ-Secretase is an intramembrane aspartyl-protease catalyzing the final step in the
regulated intramembrane proteolysis of a large number of single-span type-1 …

In situ structure and dynamics of DNA origami determined through molecular dynamics simulations

J Yoo, A Aksimentiev - … of the National Academy of Sciences, 2013 - National Acad Sciences
The DNA origami method permits folding of long single-stranded DNA into complex 3D
structures with subnanometer precision. Transmission electron microscopy, atomic force …

Signal propagation in proteins and relation to equilibrium fluctuations

C Chennubhotla, I Bahar - PLoS computational biology, 2007 - journals.plos.org
Elastic network (EN) models have been widely used in recent years for describing protein
dynamics, based on the premise that the motions naturally accessible to native structures …

Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly

D Liu, FA Thélot, JA Piccirilli, M Liao, P Yin - Nature Methods, 2022 - nature.com
High-resolution structural studies are essential for understanding the folding and function of
diverse RNAs. Herein, we present a nanoarchitectural engineering strategy for efficient …

Ribosome exit tunnel can entropically stabilize α-helices

G Ziv, G Haran, D Thirumalai - Proceedings of the National …, 2005 - National Acad Sciences
Several experiments have suggested that newly synthesized polypeptide chains can adopt
helical structures deep within the ribosome exit tunnel. We hypothesize that confinement in …

Single molecule stepping and structural dynamics of myosin x

Y Sun, O Sato, F Ruhnow, ME Arsenault, M Ikebe… - Biophysical …, 2010 - cell.com
748-Pos Structural Impact Of Myosin Methionine Oxidation Jennifer C. Klein, Nicole
Piechowski, Margaret A. Titus, David D. Thomas. Univeristy of Minnesota, Minneapolis, MN …

Dynamic charge interactions create surprising rigidity in the ER/K α-helical protein motif

S Sivaramakrishnan, BJ Spink… - Proceedings of the …, 2008 - National Acad Sciences
Protein α-helices are ubiquitous secondary structural elements, seldom considered to be
stable without tertiary contacts. However, amino acid sequences in proteins that are based …

Bond clusters control rupture force limit in shear loaded histidine-Ni 2+ metal-coordinated proteins

E Khare, DS Grewal, MJ Buehler - Nanoscale, 2023 - pubs.rsc.org
Dynamic noncovalent interactions are pivotal to the structure and function of biological
proteins and have been used in bioinspired materials for similar roles. Metal-coordination …