Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …

Mucus is a complex biological material that lubricates and protects the human lungs,
gastrointestinal (GI) tract, vagina, eyes, and other moist mucosal surfaces. Mucus serves as …

Current measurements of the biomechanical properties of cells require physical contact with
cells or lack subcellular resolution. Here we developed a label-free microscopy technique …

Bringing to life the fascinating structures and unique mechanics of natural and biomedical
cellular materials, this book is an expert guide to the subject for graduates and researchers …

A cell undergoes many genetic and epigenetic changes as it transitions to malignancy.
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …

Focal adhesions are large multi-protein assemblies that form at the basal surface of cells on
planar dishes, and that mediate cell signalling, force transduction and adhesion to the …

A multitude of cellular and subcellular processes depend critically on the mechanical
deformability of the cytoplasm. We have recently introduced the method of particle-tracking …

The interplay between the mechanical properties of cells and the forces that they produce
internally or that are externally applied to them play an important role in maintaining the …

It is now widely appreciated that normal tissue morphology and function rely upon cells'
ability to sense and generate forces appropriate to their correct tissue context. Although the …

Lamin A/C is a major constituent of the nuclear lamina, a thin filamentous protein layer that
lies beneath the nuclear envelope. Here we show that lamin A/C deficiency in mouse …