Coumarin-containing hybrids and their anticancer activities

L Zhang, Z Xu - European Journal of Medicinal Chemistry, 2019 - Elsevier
Cancer is the second leading cause of death worldwide, and it results in around 9 million
deaths annually. The anticancer agents play an intriguing role in the treatment of cancers …

[HTML][HTML] Emerging trends and future opportunities for coumarin-heterocycle conjugates as antibacterial agents

YF Mustafa - Results in Chemistry, 2023 - Elsevier
Infectious diseases resulting from various strains of pathogenic bacteria are among the
leading causes of death and morbidity worldwide. The currently-available antibacterial …

DFT studies on vibrational and electronic spectra, HOMO–LUMO, MEP, HOMA, NBO and molecular docking analysis of benzyl-3-N-(2, 4, 5 …

MA Mumit, TK Pal, MA Alam, MAAAA Islam… - Journal of molecular …, 2020 - Elsevier
Abstract Benzyl-3-N-(2, 4, 5-trimethoxyphenylmethylene) hydrazinecarbodithioate
(compound 1) is a bidentate and nitrogen-sulfur containing Schiff base, which has been …

Coumarin‐containing hybrids and their antibacterial activities

D Feng, A Zhang, Y Yang, P Yang - Archiv der Pharmazie, 2020 - Wiley Online Library
Infections caused by Gram‐positive and‐negative bacteria are one of the foremost causes of
morbidity and mortality globally. Antibiotics are the mainstay of therapy for bacterial …

Structure elucidation {single X-ray crystal diffraction studies, Hirshfeld surface analysis, DFT} and antibacterial studies of sulfonamide functionalized Schiff base …

WA Siddiqui, MA Raza, A Ashraf, M Ashfaq… - Journal of Molecular …, 2024 - Elsevier
Microbial infections tremendously affect the human health and can be cured by antimicrobial
agents. In this regard, the copper and zinc complexes of a sulfonamide functionalized Schiff …

[HTML][HTML] In vitro antimicrobial evaluation, single-point resistance study, and radiosterilization of novel pyrazole incorporating thiazol-4-one/thiophene derivatives as …

HA Mohamed, YA Ammar, GAM Elhagali, HA Eyada… - ACS …, 2022 - ncbi.nlm.nih.gov
A series of thiazol-4-one/thiophene-bearing pyrazole derivatives as pharmacologically
attractive cores were initially synthesized using a hybridization approach. All structures were …

Efficient synthesis, antibacterial, antifungal, antioxidant and cytotoxicity study of 2‐(2‐hydrazineyl) thiazole derivatives

VA Adole, RA More, BS Jagdale, TB Pawar… - …, 2020 - Wiley Online Library
In the present investigation, an alluring green PEG‐400 mediated one‐pot synthesis of
novel 2‐(2‐hydrazinyl) thiazole derivatives from 1, 2, 6, 7‐tetrahydro‐8H‐indeno [5, 4‐b] …

Exploring the antimalarial and antioxidant efficacy of transition metal (II) chelates of thiosemicarbazone ligands: spectral investigations, molecular docking, DFT, MESP …

J Devi, B Kumar, A Dubey, A Tufail, A Boora - BioMetals, 2024 - Springer
Malaria, a relentless and ancient adversary, continues to cast its shadow over vast swathes
of the globe, afflicting millions of people and have a heavy toll on human health and well …

Novel cyclohepta [b] thiophene derivative incorporating pyrimidine, pyridine, and chromene moiety as potential antimicrobial agents targeting DNA gyrase

EA Fayed, M Mohsen, SM Abd El-Gilil… - Journal of Molecular …, 2022 - Elsevier
The emergence of drug-resistant microbes is responsible for high morbidity and mortality
worldwide. In our endeavors to cultivate novel and effectual antimicrobial agents, we present …

Lipophilicity, pharmacokinetic properties, and molecular docking study on SARS-CoV-2 target for betulin triazole derivatives with attached 1, 4-quinone

M Kadela-Tomanek, M Jastrzębska, K Marciniec… - Pharmaceutics, 2021 - mdpi.com
A key parameter in the design of new active compounds is lipophilicity, which influences the
solubility and permeability through membranes. Lipophilicity affects the pharmacodynamic …