The mating pheromone a-factor secreted by Saccharomyces cerevisiae is a farnesylated
and carboxylmethylated peptide and is unusually hydrophobic compared to other …

C-Terminal cysteine peptide acids are difficult to access without epimerization of the
cysteine α-stereocenter. Diversification of the C-terminus after solid-phase peptide synthesis …

A new cysteine anchoring method was developed for the synthesis of peptides containing C-
terminal cysteine methyl esters. This method consists of attachment of Fmoc-Cys-OCH3 to …

Peptides containing C-terminal esters are an important class of bioactive molecules that
includes a-factor, a farnesylated dodecapeptide, involved in the mating of Saccharomyces …

A solid-phase S-alkylation procedure to introduce chemical modification on the cysteine
sulfhydryl group of a peptidyl resin is reported. The reaction is promoted by activated …

The ease with which populations of the budding yeast Saccharomyces cerevisiae can be
synchronized using the mating pheromone α‐factor has been invaluable for studies of the …

Protein prenylation is a post-translational modification that involves the addition of one or
two isoprenoid groups to the C-terminus of selected proteins using either farnesyl …

Saccharomyces cerevisiae yeast cells court each other by producing an attractive sex
pheromone specific to their mating type. Cells detect the sex pheromone from potential …

Protein lipidation is a post-translational modification that confers hydrophobicity on protein
substrates to control their cellular localization, mediate protein trafficking, and regulate …

Purpose Following prenylation, some proteins undergo proteolytic removal of a C-terminal
tripeptide in a reaction catalyzed by Ste24. This results in a protein terminating in a …