The emerging roles of circRNAs in cancer and oncology
LS Kristensen, T Jakobsen, H Hager… - Nature reviews Clinical …, 2022 - nature.com
Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …
non-coding RNA molecules, many of which have key roles in cancer development and …
The role of miRNAs in regulating gene expression networks
AM Gurtan, PA Sharp - Journal of molecular biology, 2013 - Elsevier
MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across
species, expressed across cell types, and active against a large proportion of the …
species, expressed across cell types, and active against a large proportion of the …
Screening for functional circular RNAs using the CRISPR–Cas13 system
Circular RNAs (circRNAs) produced from back-spliced exons are widely expressed, but
individual circRNA functions remain poorly understood owing to the lack of adequate …
individual circRNA functions remain poorly understood owing to the lack of adequate …
Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals
Stature is affected by many polymorphisms of small effect in humans. In contrast, variation in
dogs, even within breeds, has been suggested to be largely due to variants in a small …
dogs, even within breeds, has been suggested to be largely due to variants in a small …
The imprinted H19 lncRNA antagonizes let-7 microRNAs
Abundantly expressed in fetal tissues and adult muscle, the developmentally regulated H19
long noncoding RNA (lncRNA) has been implicated in human genetic disorders and cancer …
long noncoding RNA (lncRNA) has been implicated in human genetic disorders and cancer …
The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ
X Wang, Y Ji, P Feng, R Liu, G Li, J Zheng… - Advanced …, 2021 - Wiley Online Library
Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue
microenvironment. Currently, little is known about how the intrinsic regulators modulate …
microenvironment. Currently, little is known about how the intrinsic regulators modulate …
m6A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2‐mediated IGF1R mRNA stabilization
Background Bone metastasis is the leading cause of tumor‐related death in prostate cancer
(PCa) patients. Long noncoding RNAs (lncRNAs) have been well documented to be …
(PCa) patients. Long noncoding RNAs (lncRNAs) have been well documented to be …
The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells
MR Copley, S Babovic, C Benz, DJHF Knapp… - Nature cell …, 2013 - nature.com
Mouse haematopoietic stem cells (HSCs) undergo a postnatal transition in several
properties, including a marked reduction in their self-renewal activity. We now show that the …
properties, including a marked reduction in their self-renewal activity. We now show that the …
A long non-coding RNA, LncMyoD, regulates skeletal muscle differentiation by blocking IMP2-mediated mRNA translation
Increasing evidence suggests that long non-coding RNAs (LncRNAs) represent a new class
of regulators of stem cells. However, the roles of LncRNAs in stem cell maintenance and …
of regulators of stem cells. However, the roles of LncRNAs in stem cell maintenance and …
RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via …
D Yu, M Pan, Y Li, T Lu, Z Wang, C Liu, G Hu - Journal of Experimental & …, 2022 - Springer
Background Lymph node metastasis is the main cause of poor prognosis of head and neck
squamous carcinoma (HNSCC) patients. N6-methyladenosine (m6A) RNA modification is …
squamous carcinoma (HNSCC) patients. N6-methyladenosine (m6A) RNA modification is …