How do protein kinases recognize their substrates?
Abbreviations: AMP-K, AMP-activated protein kinase;/3ARK,/3 adrenergic receptor kinase;
BCKDHK, branched chain ketoglutaric acid dehydrogenase; CaM-kinases, calmodulin …
BCKDHK, branched chain ketoglutaric acid dehydrogenase; CaM-kinases, calmodulin …
The role of VCP mutations in the Spectrum of amyotrophic lateral sclerosis—frontotemporal dementia
E Scarian, G Fiamingo, L Diamanti, I Palmieri… - Frontiers in …, 2022 - frontiersin.org
Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two
neurological diseases which, respectively, and primarily affect motor neurons and …
neurological diseases which, respectively, and primarily affect motor neurons and …
[HTML][HTML] A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators
Nek2, a mammalian protein kinase of unknown function, is closely related to the mitotic
regulator NIMA of Aspergillus nidulans. Here we show by both immunofluorescence …
regulator NIMA of Aspergillus nidulans. Here we show by both immunofluorescence …
Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements
Quantum dots (Qdots) are now used extensively for labeling in biomedical research, and this
use is predicted to grow because of their many advantages over alternative labeling …
use is predicted to grow because of their many advantages over alternative labeling …
Phosphotransferase and substrate binding mechanism of the cAMP‐dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure …
D Bossemeyer, RA Engh, V Kinzel, H Ponstingl… - The EMBO …, 1993 - embopress.org
The crystal structure of the porcine heart catalytic subunit of cAMP‐dependent protein kinase
in a ternary complex with the MgATP analogue MnAMP‐PNP and a pseudosubstrate …
in a ternary complex with the MgATP analogue MnAMP‐PNP and a pseudosubstrate …
Mitotic regulation by NIMA-related kinases
The NIMA-related kinases represent a family of serine/threonine kinases implicated in cell
cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans …
cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans …
The Nek2 protein kinase: a novel regulator of centrosome structure
AM Fry - Oncogene, 2002 - nature.com
Regulation of the centrosome, the major microtubule organizing centre in an animal cell, is
in large part controlled by cell cycle-dependent protein phosphorylation. Along with cyclin …
in large part controlled by cell cycle-dependent protein phosphorylation. Along with cyclin …
Capacitation is associated with tyrosine phosphorylation and tyrosine kinase-like activity of pig sperm proteins
S Tardif, C Dubé, S Chevalier… - Biology of …, 2001 - academic.oup.com
Capacitation represents the final maturational steps that render mammalian sperm
competent to fertilize, either in vivo or in vitro. Capacitation is defined as a series of events …
competent to fertilize, either in vivo or in vitro. Capacitation is defined as a series of events …
NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
Loss-of-function mutations in NEK1 gene, which encodes a serine/threonine kinase, are
involved in human developmental disorders and ALS. Here we show that NEK1 regulates …
involved in human developmental disorders and ALS. Here we show that NEK1 regulates …
Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice
P Upadhya, EH Birkenmeier… - Proceedings of the …, 2000 - National Acad Sciences
We previously have described a mouse model for polycystic kidney disease (PKD) caused
by either of two mutations, kat or kat 2J, that map to the same locus on chromosome 8. The …
by either of two mutations, kat or kat 2J, that map to the same locus on chromosome 8. The …