Methods and compositions for performing RNA interference with decreased off-target effects
are provided The methods and compositions permit effective and efficient applications of …

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …

2004-05-18 Assigned to ISIS PHARMACEUTICALS, INC. reassignment ISIS
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

The present invention provides oligomeric compounds hav ing su? icient complementarity to
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …

Small interfering RNA (siRNA) knock down antisense transcripts, and regulate the
expression of their sense partners. This regulation can either be discordant (antisense …

US8153606B2 - Treatment of apolipoprotein-A1 related diseases by inhibition of natural
antisense transcript to apolipoprotein-A1 - Google Patents US8153606B2 - Treatment of …

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embodiments 5,214.34 A 5, 1993 Weis et al....... 536, 25.3 the modification is a 2. Substituent …

7,067,497 B2 6, 2006 Hanecak WO 94-21825 9, 1994 7,122,649 B2 10/2006 Manoharan et
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(*) Notice: Subject to any disclaimer, the term of this 5,578,718 A 1 1/1996 Cook et al. patent
is extended or adjusted under 35 5,580,767 A 12/1996 Cowsert et al. USC 154 (b) by 303 …

3,687,808 A 8, 1972 Merigan et al.................. 195/28 4,373,071 A 2/1983
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