An early detection and intervention for dementia represent tremendous unmet clinical needs
and priorities in society. A shared feature of neurodegenerative diseases causing dementia …

Supramolecular assembly affords the development of a wide range of polypeptide-based
biomaterials for drug delivery and nanomedicine. However, there remains a need to develop …

Glutarate is a key monomer in polyester and polyamide production. The low efficiency of the
current biosynthetic pathways hampers its production by microbial cell factories. Herein …

Molecular docking is a bioinformatics-based theoretical simulation strategy. It is employed to
study ligand-protein interaction profiles and predict their binding conformers and affinity …

Proteolysis targeting chimeras (PROTACs) are molecules that induce protein degradation
via formation of ternary complexes between an E3 ubiquitin ligase and a target protein. The …

Kinases have been the focus of drug discovery programs for three decades leading to over
70 therapeutic kinase inhibitors and biophysical affinity measurements for over 130,000 …

Abstract KRAS G12D is the most common oncogenic mutation identified in several types of
cancer. Therefore, design of inhibitors targeting KRAS G12D represents a promising …

Nuclear receptors function as ligand-regulated transcription factors whose ability to regulate
diverse physiological processes is closely linked with conformational changes induced upon …

We have performed dynamic docking between a prototypic G-protein-coupled receptor
(GPCR) system, the β2-adrenergic receptor, and its antagonist, alprenolol, using one of the …

The structure of hexameric glutamate dehydrogenase (GDH) in the presence of the
coenzyme nicotinamide adenine dinucleotide phosphate (NADP) was visualized using …