Knowledge of aging biology needs to be expanded due to the continuously growing number
of elderly people worldwide. Aging induces changes that affect all systems of the body. The …

CD4+ T cells play a notable role in immune protection at different stages of life. During
aging, the interaction between the body's internal and external environment and CD4+ T …

Extensive research has been carried out to understand and elucidate the mechanisms of
paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular …

As we age, our immune system's ability to effectively respond to pathogens declines, a
phenomenon known as immunosenescence. This age-related deterioration affects both …

The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly
people are mostly unknown. We studied individuals older than 60 and younger than 60 …

The immune system comprises multiple cell lineages and heterogeneous subsets found in
blood and tissues throughout the body. While human immune responses differ between …

The gut microbiome plays a critical role in maintaining overall health and immune function.
However, dysbiosis, an imbalance in microbiome composition, can have profound effects on …

Background: Multiple sclerosis (MS) is a chronic autoimmune disease damaging the central
nervous system. Diminished inflammatory disease activities (DAs) as people with MS …

More than 40 years after the first reported cases of what then became known as acquired
immunodeficiency syndrome (AIDS), tremendous progress has been achieved in …

Understanding the perturbed lung immune cell distribution and their functionality in
tuberculosis is well documented; however, limited reports covered their disruption, if any, in …