History of the development of antifungal azoles: A review on structures, SAR, and mechanism of action

M Shafiei, L Peyton, M Hashemzadeh, A Foroumadi - Bioorganic chemistry, 2020 - Elsevier
With the increasing risk of invasive and life threating fungal infections, there is now a great
concern regarding the lower discovery rate of antifungal drugs in comparison to …

A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise

KC Howard, EK Dennis, DS Watt… - Chemical Society …, 2020 - pubs.rsc.org
The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

A recent overview of 1, 2, 3‐triazole‐containing hybrids as novel antifungal agents: Focusing on synthesis, mechanism of action, and structure‐activity relationship …

M Marzi, M Farjam, Z Kazeminejad… - Journal of …, 2022 - Wiley Online Library
A pharmacophore system has been found as 1, 2, 3‐triazole, a five‐membered heterocycle
ring with nitrogen heteroatoms. These heterocyclic compounds can be produced using …

From screening to the hectogram scale: sustainable electrochemical synthesis of mefenpyr-diethyl

M Linden, S Hofmann, FN Weber, RM Bär… - Green …, 2023 - pubs.rsc.org
To demonstrate the technical application potential of electrochemical reactions, we
developed a synthetic method to access the commercially available herbicide safener …

Synthesis and biological evaluation of new 2‑substituted‑4‑amino-quinolines and-quinazoline as potential antifungal agents

TH Qin, JC Liu, JY Zhang, LX Tang, YN Ma… - Bioorganic & Medicinal …, 2022 - Elsevier
Aiming to discover novel antifungal agents, a series of 2‑substituted‑4‑amino-quinolines and-
quinazoline were prepared and characterized using IR, 1 H NMR, 13 C NMR, and HRMS …

Visible Light-driven, gold (I)-catalyzed preparation of symmetrical (hetero) biaryls by homocoupling of arylazo sulfones

L Di Terlizzi, S Scaringi, C Raviola… - The Journal of …, 2022 - ACS Publications
The preparation of symmetrical (hetero) biaryls via arylazo sulfones has been successfully
carried out upon visible light irradiation in the presence of PPh3AuCl as the catalyst. The …

Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation

Y An, Y Dong, M Liu, J Han, L Zhao, B Sun - European Journal of Medicinal …, 2021 - Elsevier
Fungal infections have become a serious medical problem due to the high infection rate and
the frequent emergence of drug resistance. Squalene epoxidase (SE) and 14α-demethylase …

Distorted gold (I)–phosphine complexes as antifungal agents

EK Dennis, JH Kim, S Parkin, SG Awuah… - Journal of medicinal …, 2019 - ACS Publications
Fungi cause serious nosocomial infections including candidiasis and aspergillosis, some of
which display reduced susceptibility to current antifungals. Inorganic compounds have been …

Broad‐Spectrum Antifungal Agents: Fluorinated Aryl‐and Heteroaryl‐Substituted Hydrazones

N Thamban Chandrika, EK Dennis… - …, 2021 - Wiley Online Library
Fluorinated aryl‐and heteroaryl‐substituted monohydrazones displayed excellent broad‐
spectrum activity against various fungal strains, including a panel of clinically relevant …

Molecular exploration of hidden pleiotropic activities of azoles on dermatophytes in human tinea corporis infection

KS Alharbi, N Joshi, Y Singh, I Kazmi… - Journal of Medical …, 2022 - Elsevier
Dermatophyte infections are widespread worldwide and are the most prevalent cause of
fungal infection of the skin, hair, and nails. Tinea corporis is most commonly caused by …