Inositol 1, 4, 5‐trisphosphate receptors and neurodegenerative disorders

PA Egorova, IB Bezprozvanny - The FEBS journal, 2018 - Wiley Online Library
The inositol 1, 4, 5‐trisphosphate receptor (IP 3R) is an intracellular ion channel that
mediates the release of calcium ions from the endoplasmic reticulum. It plays a role in basic …

Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease

R Vidal, B Caballero, A Couve… - Current molecular …, 2011 - ingentaconnect.com
A variety of neurological diseases including Huntington's disease (HD), Alzheimer's disease
and Parkinson's disease share common neuropathology, primarily featuring the presence of …

Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex

A Scior, A Buntru, K Arnsburg, A Ast, M Iburg… - The EMBO …, 2018 - embopress.org
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG
trinucleotide repeat in the huntingtin gene (HTT). Molecular chaperones have been …

NanoEHS beyond toxicity–focusing on biocorona

S Lin, M Mortimer, R Chen, A Kakinen… - Environmental …, 2017 - pubs.rsc.org
The first phase of studies on environmental health and safety of nanomaterials (nanoEHS)
has been mainly focused on evidence-based investigations that probe the impact of …

Gut-brain axis deregulation and its possible contribution to neurodegenerative disorders

F Villavicencio-Tejo, MA Olesen, L Navarro… - Neurotoxicity …, 2024 - Springer
The gut-brain axis is an essential communication pathway between the central nervous
system (CNS) and the gastrointestinal tract. The human microbiota is composed of a diverse …

A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington's disease mice

N Suelves, L Kirkham-McCarthy, RS Lahue, S Ginés - Scientific reports, 2017 - nature.com
Huntington's disease (HD) is a neurodegenerative disorder whose major symptoms include
progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life …

Polyglutamine expansion in huntingtin and mechanism of DNA damage repair defects in Huntington's disease

S Pradhan, R Gao, K Bush, N Zhang… - Frontiers in Cellular …, 2022 - frontiersin.org
Emerging evidence suggests that DNA repair deficiency and genome instability may be the
impending signs of many neurological diseases. Genome-wide association (GWAS) studies …

[HTML][HTML] Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions

L Diaz-Hidalgo, S Altuntas, F Rossin, M D'Eletto… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Numerous studies are revealing a role of exosomes in intercellular communication, and
growing evidence indicates an important function for these vesicles in the progression and …

Cannabinoid cb2 receptors in neurodegenerative proteinopathies: New insights and therapeutic potential

B Vuic, T Milos, L Tudor, M Konjevod… - Biomedicines, 2022 - mdpi.com
Some of the most prevalent neurodegenerative disorders, including Alzheimer's and
Parkinson's disease, are proteinopathies characterized by the accumulation of specific …

[HTML][HTML] An emerging role for stress granules in neurodegenerative disease and hearing loss

JL Martin, SJ Dawson, JE Gale - Hearing Research, 2022 - Elsevier
Stress granules (SGs) are membrane-less cytosolic assemblies that form in response to
stress (eg, heat, oxidative stress, hypoxia, viral infection and UV). Composed of mRNA, RNA …