Inositol 1, 4, 5‐trisphosphate receptors and neurodegenerative disorders
PA Egorova, IB Bezprozvanny - The FEBS journal, 2018 - Wiley Online Library
The inositol 1, 4, 5‐trisphosphate receptor (IP 3R) is an intracellular ion channel that
mediates the release of calcium ions from the endoplasmic reticulum. It plays a role in basic …
mediates the release of calcium ions from the endoplasmic reticulum. It plays a role in basic …
Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease
R Vidal, B Caballero, A Couve… - Current molecular …, 2011 - ingentaconnect.com
A variety of neurological diseases including Huntington's disease (HD), Alzheimer's disease
and Parkinson's disease share common neuropathology, primarily featuring the presence of …
and Parkinson's disease share common neuropathology, primarily featuring the presence of …
Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex
A Scior, A Buntru, K Arnsburg, A Ast, M Iburg… - The EMBO …, 2018 - embopress.org
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG
trinucleotide repeat in the huntingtin gene (HTT). Molecular chaperones have been …
trinucleotide repeat in the huntingtin gene (HTT). Molecular chaperones have been …
NanoEHS beyond toxicity–focusing on biocorona
The first phase of studies on environmental health and safety of nanomaterials (nanoEHS)
has been mainly focused on evidence-based investigations that probe the impact of …
has been mainly focused on evidence-based investigations that probe the impact of …
Gut-brain axis deregulation and its possible contribution to neurodegenerative disorders
The gut-brain axis is an essential communication pathway between the central nervous
system (CNS) and the gastrointestinal tract. The human microbiota is composed of a diverse …
system (CNS) and the gastrointestinal tract. The human microbiota is composed of a diverse …
A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington's disease mice
N Suelves, L Kirkham-McCarthy, RS Lahue, S Ginés - Scientific reports, 2017 - nature.com
Huntington's disease (HD) is a neurodegenerative disorder whose major symptoms include
progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life …
progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life …
Polyglutamine expansion in huntingtin and mechanism of DNA damage repair defects in Huntington's disease
Emerging evidence suggests that DNA repair deficiency and genome instability may be the
impending signs of many neurological diseases. Genome-wide association (GWAS) studies …
impending signs of many neurological diseases. Genome-wide association (GWAS) studies …
[HTML][HTML] Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions
L Diaz-Hidalgo, S Altuntas, F Rossin, M D'Eletto… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Numerous studies are revealing a role of exosomes in intercellular communication, and
growing evidence indicates an important function for these vesicles in the progression and …
growing evidence indicates an important function for these vesicles in the progression and …
Cannabinoid cb2 receptors in neurodegenerative proteinopathies: New insights and therapeutic potential
Some of the most prevalent neurodegenerative disorders, including Alzheimer's and
Parkinson's disease, are proteinopathies characterized by the accumulation of specific …
Parkinson's disease, are proteinopathies characterized by the accumulation of specific …
[HTML][HTML] An emerging role for stress granules in neurodegenerative disease and hearing loss
Stress granules (SGs) are membrane-less cytosolic assemblies that form in response to
stress (eg, heat, oxidative stress, hypoxia, viral infection and UV). Composed of mRNA, RNA …
stress (eg, heat, oxidative stress, hypoxia, viral infection and UV). Composed of mRNA, RNA …