Nanopore-based sensors have established themselves as a prominent tool for solution-
based, single-molecule analysis of the key building blocks of life, including nucleic acids …

This review discusses a relatively new technique for optical nanoimaging at visible
wavelength, known as tip-enhanced Raman spectroscopy (TERS). This technique relies on …

Plasmonic and nanopore sensors have separately received much attention for achieving
single‐molecule precision. A plasmonic “hotspot” confines and enhances optical excitation …

Plasmonics is the discipline that investigates the use of collective oscillations of conductive
electrons in metallic nanostructures, called surface plasmons (SPs), to realize a large set of …

Electromagnetic forces and torques enable many key technologies, including optical
tweezers or dielectrophoresis. Interestingly, both techniques rely on the same physical …

Sequence identification of peptides and proteins is central to proteomics. Protein
sequencing is mainly conducted by insensitive mass spectroscopy because proteins cannot …

There has been a significant drive to deliver nanotechnological solutions to biosensing, yet
there remains an unmet need in the development of biosensors that are affordable …

Identifying nanoscale biomolecules in aqueous solutions by Fourier transform infrared
spectroscopy (FTIR) provides an in situ and noninvasive method for exploring the structure …

The detection of biomolecules is the key to basic molecular research, diagnostics, drug
screening, and other biomedical applications. However, the existing detection techniques …

The ability to measure biomarkers, both specifically and selectively at the single‐molecule
level in biological fluids, has the potential to transform the diagnosis, monitoring, and …