The membrane protein Nogo-A was initially characterized as a CNS-specific inhibitor of
axonal regeneration. Recent studies have uncovered regulatory roles of Nogo proteins and …

Investigations of synaptic transmission and plasticity in mouse models of Huntington's
disease (HD) demonstrate neuronal dysfunction long before the onset of classical disease …

Injury or insult to the adult nervous system often results in reactivation of signaling pathways
that are normally only active during development. The p75 neurotrophin receptor (p75 NTR) …

Axon degeneration initiated by trophic factor withdrawal shares many features with
programmed cell death, but many prior studies discounted a role for caspases in this …

The precise wiring of the nervous system is a combined outcome of progressive and
regressive events during development. Axon guidance and synapse formation intertwined …

Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a
significant cause of mortality around the world. On a molecular level, the condition is …

Axonal damage leads to permanent deficits in the adult central nervous system (CNS) not
only because of the weak intrinsic ability of adult neurons to activate their growth program …

Neurons can activate pathways that destroy the whole cell via apoptosis or selectively
degenerate only the axon (pruning). Both apoptosis and axon degeneration require Bax and …

Huntington disease (HD) is a neurodegenerative disorder caused by an elongated
polyglutamine tract in huntingtin (htt). htt normally undergoes different posttranslational …

The p75 neurotrophin receptor (p75 NTR) regulates a wide range of cellular functions,
including programmed cell death, axonal growth and degeneration, cell proliferation …