Recent advanced in bioactive systems containing pyrazole fused with a five membered heterocycle

D Raffa, B Maggio, MV Raimondi, S Cascioferro… - European journal of …, 2015 - Elsevier
In this review we report the recent advances in bioactive system containing pyrazole fused
with a five membered heterocycle, covering the time span of the last decade. All of them are …

[PDF][PDF] Pyrazole: a versatile moiety

A Chauhan, PK Sharma, N Kaushik - Int. J. ChemTech Res, 2011 - researchgate.net
The aim of this review is to provide an overview of diverse pharmacological activities of
pyrazole moiety. This review highlighted recent reports of antimicrobial, anticancer, ACE …

Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents

PC Lv, HQ Li, J Sun, Y Zhou, HL Zhu - Bioorganic & medicinal chemistry, 2010 - Elsevier
Two series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been
discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(3, 4 …

Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety

İ Koca, A Özgür, KA Coşkun, Y Tutar - Bioorganic & medicinal chemistry, 2013 - Elsevier
In this work novel organic based compounds, acyl thiourea derivatives were synthesized
and their anticancer activities were investigated. A new series of acyl thiourea derivatives …

Synthesis and antiviral activity of 4, 4′-(arylmethylene) bis (1H-pyrazol-5-ols) against peste des petits ruminant virus (PPRV)

K Sujatha, G Shanthi, NP Selvam, S Manoharan… - Bioorganic & medicinal …, 2009 - Elsevier
An efficient and eco-friendly method for the synthesis of 4, 4′-(arylmethylene) bis (1H-
pyrazol-5-ols) has been accomplished by tandem Knoevenagel–Michael reaction of two …

Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents

PC Lv, DD Li, QS Li, X Lu, ZP Xiao, HL Zhu - Bioorganic & medicinal …, 2011 - Elsevier
Fourty-two thiazolyl-pyrazoline derivatives were synthesized to screen for their EGFR kinase
inhibitory activity. Compound 4-(4-chlorophenyl)-2-(3-(3, 4-dimethylphenyl)-5-p-tolyl-4, 5 …

Synthesis of some new pyrazole-based 1, 3-thiazoles and 1, 3, 4-thiadiazoles as anticancer agents

KM Dawood, TMA Eldebss, HSA El-Zahabi… - European journal of …, 2013 - Elsevier
Abstract N-(4-(Pyrazol-4-yl) thiazol-2-yl)-N′-phenylthiourea derivative 2 was synthesized
and then treated with variety of hydrazonoyl chlorides under basic condition at reflux to …

Synthetic pyrazole derivatives as growth inhibitors of some phytopathogenic fungi

CB Vicentini, C Romagnoli, E Andreotti… - Journal of agricultural …, 2007 - ACS Publications
The present study was carried out to investigate the antifungal activity of pyrazole/isoxazole-
3-carboxamido-4-carboxylic acids, 4-oxo-5-substituted pyrazolo [3, 4-d] pyrimidine-6 …

Novel N-bridged pyrazole-1-carbothioamides With Potential Antiproliferative Activity: design, synthesis, In Vitro and In Silico Studies

IH El Azab, EM Saied, AA Osman… - Future Medicinal …, 2021 - Taylor & Francis
Thiazole-substituted pyrazole is an important structural feature of many bioactive
compounds, including antiviral, antitubercular, analgesic and anticancer agents. Herein we …

Synthesis and anti-microbial activity of pyrazolylbisindoles—promising anti-fungal compounds

G Sivaprasad, PT Perumal, VR Prabavathy… - Bioorganic & medicinal …, 2006 - Elsevier
A series of pyrazolylbisindole derivatives have been synthesized by reacting substituted
pyrazole aldehydes with substituted indoles using phosphotungstic acid, a Keggin type …