Integral membrane proteins are involved in a plethora of biological processes including
cellular signalling, molecular transport, and catalysis. Many of these functions are mediated …

The mammalian membrane is composed of various eukaryotic lipids interacting with
extensively post-translationally modified proteins. Probing interactions between these …

Cyclic nucleotide-gated (CNG) channels transduce chemical signals into electrical signals in
sensory receptors and neurons. They are activated by cGMP or cAMP, which bind to the …

Class C G-protein-coupled receptors (GPCRs) are activated through binding of agonists to
the large extracellular domain (ECD) followed by rearrangement of the transmembrane …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for
pacemaking activity and neural signalling,. Drugs inhibiting HCN1 are promising candidates …

Native mass spectrometry (nMS) has emerged as a key analytical tool to study the
organizational states of proteins and their complexes with both endogenous and exogenous …

Abstract The signaling lipid phosphatidylinositol-4, 5-bisphosphate (PIP2) regulates many
ion channels. It inhibits eukaryotic cyclic nucleotide-gated (CNG) channels while activating …

Hyperpolarization and cyclic nucleotide (HCN) activated ion channels are critical for the
automaticity of action potentials in pacemaking and rhythmic electrical circuits in the human …

Ion channels function within a membrane environment characterized by dynamic lipid
compartmentalization. Limited knowledge exists regarding the response of voltage-gated …

Understanding how ion channels gate is important for elucidating their physiological roles
and targeting them in pathophysiological states. Here, we used SthK, a cyclic nucleotide …