Overcoming intrinsic and acquired resistance mechanisms associated with the cell wall of gram-negative bacteria
RE Impey, DA Hawkins, JM Sutton… - Antibiotics, 2020 - mdpi.com
The global increase in multi-drug-resistant bacteria is severely impacting our ability to
effectively treat common infections. For Gram-negative bacteria, their intrinsic and acquired …
effectively treat common infections. For Gram-negative bacteria, their intrinsic and acquired …
[HTML][HTML] Functional characterization of prokaryotic dark matter: the road so far and what lies ahead
P Escudeiro, CS Henry, RPM Dias - Current Research in Microbial …, 2022 - Elsevier
Eight-hundred thousand to one trillion prokaryotic species may inhabit our planet. Yet, fewer
than two-hundred thousand prokaryotic species have been described. This uncharted …
than two-hundred thousand prokaryotic species have been described. This uncharted …
Synthesis and structure-activity relationship studies of 2, 4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase
Dihydrodipicolinate synthase (DHDPS), responsible for the first committed step of the
diaminopimelate pathway for lysine biosynthesis, has become an attractive target for the …
diaminopimelate pathway for lysine biosynthesis, has become an attractive target for the …
Experimental investigation of enzyme functional annotations reveals extensive annotation error
E Rembeza, MKM Engqvist - bioRxiv, 2020 - biorxiv.org
Only a small fraction of genes deposited to databases has been experimentally
characterised. The majority of proteins have their function assigned automatically, which can …
characterised. The majority of proteins have their function assigned automatically, which can …
Enhancement of Edwardsiella piscicida infection, biofilm formation, and motility caused by N-acetylneuraminate lyase
LK Vo, NT Tran, Y Kubo, D Sahashi, M Komatsu… - Glycoconjugate …, 2022 - Springer
Sialic acid and its catabolism are involved in bacterial pathogenicity. N-acetylneuraminate
lyase (NAL), which catalyzes the reversible aldol cleavage of sialic acid to form N-acetyl-D …
lyase (NAL), which catalyzes the reversible aldol cleavage of sialic acid to form N-acetyl-D …
The First Inhibitor of Meso-Diaminopimelate Biosynthesis with Antibacterial Activity Against Multi-Drug Resistant Bacteria
TP Soares da Costa, JA Wyllie, CK Ghardi, MD Hulett… - bioRxiv, 2022 - biorxiv.org
Antibiotic resistance represents one of the biggest threats to global health. While several of
our current antibiotics target the peptidoglycan within the bacterial cell wall, only a fraction of …
our current antibiotics target the peptidoglycan within the bacterial cell wall, only a fraction of …