The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Cytochrome c oxidase is discussed as a possible photoacceptor when cells are irradiated
with monochromatic red to near-IR radiation. Four primary action mechanisms are reviewed …

The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

The heme biosynthetic and catabolic pathways generate pro-and antioxidant compounds,
and consequently, influence cellular sensitivity to oxidants. Heme precursors (δ …

We have shown that UVA (320-380 nm) radiation, hydrogen peroxide, and sodium arsenite
induce a stress protein of approximately 32 kDa in human skin fibroblasts. The synthesis …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

The metallothioneins (MT) are small, cysteine-rich heavy metal-binding proteins which
participate in an array of protective stress responses. Although a single essential function of …

The discovery of the gaseous molecule nitric oxide in 1987 unraveled investigations on its
functional role in the pathogenesis of a wide spectrum of biological and pathological …

Cellular DNA damage under prooxidant conditions has been shown to be mediated by iron.
In fact, iron is an important element in the establishment of a prooxidant status in the cell. It is …

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. HO exists as …