Disruption of bone remodelling by diseases such as osteoporosis results in an imbalance
between bone formation by osteoblasts and resorption by osteoclasts. Research into these …

Periprosthetic osteolysis (PPO) induced by wear particles is an important cause of aseptic
loosening after artificial joint replacement, among which the imbalance of osteogenesis and …

This paper addresses a significant paradox in biomaterials science; biocompatibility
phenomena have been experienced and described for over 50 years but without an agreed …

Drug research with animal models is expensive, time-consuming and translation to clinical
trials is often poor, resulting in a desire to replace, reduce, and refine the use of animal …

Differentiation of stem cells is influenced by many factors, yet uptake of the magnetic
particles with or without magnetic field is rarely tackled. In this study, iron oxide …

Synchronization of material resorption and new bone formation is vital to achieve
harmonious bone regeneration in the treatment of large bone defects. To exposit the …

There are many challenges in the development of 3D-tissue models for studying bone
physiology and disease. Silk fibroin (SF), a natural fibrous protein used in biomedical …

Objectives Fluorine, an organic trace element, has been shown to unfavourably effect
osteoclasts function at a low dose. Use of hydroxyapatite (HA) has been effective in …

Differentiation of mesenchymal stem cells (MSCs) is regulated by multivariate physical and
chemical signals in a complicated microenvironment. In this study, polymerizable double …

The goal of this study was to explore the effects of osteoporosis-related therapeutics on
bone remodeling in vitro. A previously established bone-tissue mimetic system consisting of …