Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than
700 species, have always been one of the focuses for new drug discovery. These venomous …

Venom and poison peptides are powerful biological weapons and have proven immense
pharmacological potential because of their high binding affinity to a wide range of molecular …

The intense pain induced by scorpion sting is a frequent clinical manifestation. To date,
there is no established protocol with significant efficacy to alleviate the pain induced by …

The venom of each Conus species consists of a diverse array of neurophysiologically active
peptides, which are mostly unique to the examined species. In this study, we performed high …

ABSTRACT Background: The venom of Phoneutria nigriventer spider is a source of
numerous bioactive substances, including some toxins active in insects. An example is …

Pain is a major symptom of many diseases and results in enormous pressures on human
body or society. Currently, clinically used analgesic drugs, including opioids and …

Background: Scorpion neurotoxins such as those that modify the mammalian voltage-gated
sodium ion channels (Nav) are the main responsible for scorpion envenomation. Their …

Background A combination of pharmacological and biomedical assays was applied in this
study to examine the bioactivity of Conus virgo crude venom in order to determine the …

All living organisms have their own arsenal of peptides that are responsible for vital
biological functions. With an outstanding diversity of structures and modes of action …

烟碱型乙酰胆碱受体(nAChRs) 广泛分布于肌肉, 中枢神经系统和外周神经系统中,
与各种疾病的发生密切相关. 其中, α9α10 亚型是近年来发现的新型乙酰胆碱受体家族成员之一 …