Epigenetics of male infertility: the role of DNA methylation

JC Rotondo, C Lanzillotti, C Mazziotta… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

[HTML][HTML] Obesity, male infertility, and the sperm epigenome

JR Craig, TG Jenkins, DT Carrell, JM Hotaling - Fertility and sterility, 2017 - Elsevier
Obesity is a growing epidemic and a common problem among reproductive-age men that
can both cause and exacerbate male-factor infertility by means of endocrine abnormalities …

The preconception environment and sperm epigenetics

C Marcho, OA Oluwayiose, JR Pilsner - Andrology, 2020 - Wiley Online Library
Background Infertility is a common reproductive disorder, with male factor infertility
accounting for approximately half of all cases. Taking a paternal perceptive, recent research …

Sperm morphology: assessment, pathophysiology, clinical relevance, and state of the art in 2017

N Gatimel, J Moreau, J Parinaud, RD Léandri - Andrology, 2017 - Wiley Online Library
For over 30 years, sperm morphology assessment has been one of the most common tests
in evaluation of fertility. This review examines the clinical relevance of sperm morphology …

Impairment of sperm DNA methylation in male infertility: a meta‐analytic study

D Santi, S De Vincentis, E Magnani, G Spaggiari - Andrology, 2017 - Wiley Online Library
Considering the widespread use of assisted reproductive techniques (ART), DNA
methylation of specific genes involved in spermatogenesis achieves increasingly clinical …

Cigarette smoking significantly alters sperm DNA methylation patterns

TG Jenkins, ER James, DF Alonso, JR Hoidal… - …, 2017 - Wiley Online Library
Numerous health consequences of tobacco smoke exposure have been characterized, and
the effects of smoking on traditional measures of male fertility are well described. However, a …

DNA methylation in human sperm: a systematic review

F Åsenius, AF Danson, SJ Marzi - Human reproduction update, 2020 - academic.oup.com
BACKGROUND Studies in non-human mammals suggest that environmental factors can
influence spermatozoal DNA methylation, and some research suggests that spermatozoal …

Association between obesity and sperm quality

GA Ramaraju, S Teppala, K Prathigudupu… - Andrologia, 2018 - Wiley Online Library
There is awareness of likelihood of abnormal spermatozoa in obese men; however, results
from previous studies are inconclusive. Advances in computer‐aided sperm analysis …

[HTML][HTML] Prenatal exposure to phthalates and peripheral blood and buccal epithelial DNA methylation in infants: an epigenome-wide association study

G England-Mason, SM Merrill, N Gladish… - Environment …, 2022 - Elsevier
Background Prenatal exposure to phthalates has been associated with adverse health and
neurodevelopmental outcomes. DNA methylation (DNAm) alterations may be a mechanism …

[HTML][HTML] Epigenetic age prediction in semen–marker selection and model development

A Pisarek, E Pośpiech, A Heidegger, C Xavier… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
DNA methylation analysis is becoming increasingly useful in biomedical research and
forensic practice. The discovery of differentially methylated sites (DMSs) that continuously …