Extracellular‐signal‐regulated kinase/mitogen‐activated protein kinase signaling as a target for cancer therapy: an updated review
Mitogen‐activated protein kinase (MAPK) signaling pathway is activated in a wide spectrum
of human tumors, exhibiting cardinal oncogenic roles and sustained inhibition of this …
of human tumors, exhibiting cardinal oncogenic roles and sustained inhibition of this …
[HTML][HTML] Progress in the Management of Malignant PleuraláMesothelioma in 2017
AJ McCambridge, A Napolitano, AS Mansfield… - Journal of Thoracic …, 2018 - Elsevier
Malignant pleural mesothelioma (MPM) is an uncommon, almost universally fatal, asbestos-
induced malignancy. New and effective strategies for diagnosis, prognostication, and …
induced malignancy. New and effective strategies for diagnosis, prognostication, and …
[HTML][HTML] Targeting YB-1 via entinostat enhances cisplatin sensitivity of pleural mesothelioma in vitro and in vivo
K Schelch, D Emminger, B Zitta, TG Johnson, V Kopatz… - Cancer Letters, 2023 - Elsevier
Pleural mesothelioma (PM) is characterized by poor prognosis and limited therapeutic
options. Y-box-binding protein 1 (YB-1) was shown to drive growth and migration of PM …
options. Y-box-binding protein 1 (YB-1) was shown to drive growth and migration of PM …
Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma
Background More than half of mesothelioma tumours show alterations in the tumour
suppressor gene BAP1. BAP1-deficient mesothelioma is shown to be sensitive to EZH2 …
suppressor gene BAP1. BAP1-deficient mesothelioma is shown to be sensitive to EZH2 …
Biological responses to asbestos inhalation and pathogenesis of asbestos-related benign and malignant disease
E Solbes, RW Harper - Journal of Investigative Medicine, 2018 - journals.sagepub.com
Asbestos comprises a group of fibrous minerals that are naturally occurring in the
environment. Because of its natural properties, asbestos gained popularity for commercial …
environment. Because of its natural properties, asbestos gained popularity for commercial …
Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma
More than half of patients with malignant mesothelioma show alterations in the BAP1 tumor-
suppressor gene. Being a member of the Polycomb repressive deubiquitinating (PR-DUB) …
suppressor gene. Being a member of the Polycomb repressive deubiquitinating (PR-DUB) …
Genomics and functional genomics of malignant pleural mesothelioma
E Cakiroglu, S Senturk - International Journal of Molecular Sciences, 2020 - mdpi.com
Malignant pleural mesothelioma (MPM) is a rare, aggressive cancer of the mesothelial cells
lining the pleural surface of the chest wall and lung. The etiology of MPM is strongly …
lining the pleural surface of the chest wall and lung. The etiology of MPM is strongly …
Use of preclinical models for malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) is an aggressive cancer most commonly caused by
prior exposure to asbestos. Median survival is 12–18 months, since surgery is ineffective …
prior exposure to asbestos. Median survival is 12–18 months, since surgery is ineffective …
Why be one protein when you can affect many? The multiple roles of YB-1 in lung cancer and mesothelioma
Lung cancers and malignant pleural mesothelioma (MPM) have some of the worst 5-year
survival rates of all cancer types, primarily due to a lack of effective treatment options for …
survival rates of all cancer types, primarily due to a lack of effective treatment options for …
BAP1 loss is associated with higher ASS1 expression in epithelioid mesothelioma: Implications for therapeutic stratification
SE Barnett, J Kenyani, M Tripari, Z Butt… - Molecular Cancer …, 2023 - AACR
The nuclear deubiquitylase BRCA1-associated protein 1 (BAP1) is frequently inactivated in
malignant pleural mesothelioma (MPM) and germline BAP1 mutation predisposes to …
malignant pleural mesothelioma (MPM) and germline BAP1 mutation predisposes to …