Small RNA modifications: regulatory molecules and potential applications

Q Xiong, Y Zhang - Journal of Hematology & Oncology, 2023 - Springer
Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric
ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of …

[HTML][HTML] N6-methyladenosine modification and metabolic reprogramming of digestive system malignancies

X Cai, C Liang, M Zhang, Y Xu, Y Weng, X Li, W Yu - Cancer Letters, 2022 - Elsevier
Abstract N 6-methyladenosine (m6A) is a eukaryotic post-transcriptional modification
involved in cell growth and developmental processes, including RNA transcription …

Cancer-associated fibroblast–derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance

J Zhuang, L Shen, M Li, J Sun, J Hao, J Li, Z Zhu, S Ge… - Cancer research, 2023 - AACR
Cancer stem-like cells (CSC) play pivotal roles in both chemoresistance and recurrence of
many cancer types, including urothelial bladder cancer (UBC). In addition to intrinsic …

Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma

W Dai, R Tian, L Yu, S Bian, Y Chen, B Yin… - Nature …, 2024 - nature.com
Oncolytic virotherapy holds promise for cancer treatment, but the factors determining its
oncolytic activity remain unclear. Neutrophil extracellular traps (NETs) are associated with …

Recent advances in melittin-based nanoparticles for antitumor treatment: from mechanisms to targeted delivery strategies

X Yu, S Jia, S Yu, Y Chen, C Zhang, H Chen… - Journal of …, 2023 - Springer
As a naturally occurring cytolytic peptide, melittin (MLT) not only exhibits a potent direct
tumor cell-killing effect but also possesses various immunomodulatory functions. MLT shows …

METTL3-Mediated m6A Modification of lncRNA MALAT1 Facilitates Prostate Cancer Growth by Activation of PI3K/AKT Signaling

Y Mao, W Li, YM Weng, B Hua, X Gu, C Lu… - Cell …, 2022 - journals.sagepub.com
Accumulating data show that N6-methyladenosine (m6A) methyltransferase METTL3 and
long noncoding RNA MALAT1 act pivotal roles in multiple malignancies including prostate …

[HTML][HTML] Novel insights into the interplay between m6A modification and programmed cell death in cancer

J Chen, M Ye, J Bai, C Hu, F Lu, D Gu… - International journal of …, 2023 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) methylation, the most prevalent and abundant RNA
modification in eukaryotes, has recently become a hot research topic. Several studies have …

[HTML][HTML] Targeted m6A demethylation of ITGA6 mRNA by a multisite dCasRx–m6A editor inhibits bladder cancer development

X Ying, Y Huang, B Liu, WY Hu, D Ji, C Chen… - Journal of Advanced …, 2024 - Elsevier
Abstract Introduction N6-methyladenosine (m 6 A) modification contributes to the
pathogenesis and development of various cancers, including bladder cancer (BCa). In …

MicroRNA-30c-5p arrests bladder cancer G2/M phase and suppresses its progression by targeting PRC1-mediated blocking of CDK1/Cyclin B1 axis

Y Hao, Y Zhu, F Sun, D Xu, C Wang - Cellular Signalling, 2023 - Elsevier
Background MicroRNAs (miRNAs) play a critical role in cancer development and
progression, the dis-regulation of miR-30c-5p has been observed in various malignant …

Emerging Mutual Regulatory Roles between m6A Modification and microRNAs

Z Mei, Y Mou, N Zhang, X Liu, Z He, S Gu - International Journal of …, 2023 - mdpi.com
N6-metyladenosine (m6A), one of the most common RNA methylation modifications in
mammals, has attracted extensive attentions owing to its regulatory roles in a variety of …