In nature, the self-assembly of sequence-specific biopolymers into hierarchical structures
plays an essential role in the construction of functional biomaterials. To develop synthetic …

Unnatural helical peptidic foldamers have attracted considerable attention owing to their
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …

Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

In most general terms, polymers and their supramolecular assemblies have been defining
life on this planet since its conception. Polymers of nucleic acids carry the code of life and …

Antimicrobial peptides (AMPs) and their mimics are emerging as promising antibiotic agents.
We present a library of “ampetoids”(antimicrobial peptoid oligomers) with helical structures …

The highly refined organic chemistry in solid-phase synthesis has made it the method of
choice not only to assemble peptides but also small proteins–mainly on a laboratory scale …

Polymer sequence programmability is required for the diverse structures and complex
properties that are achieved by native biological polymers, but efforts towards controlling the …

Polypeptides are fascinating materials with unique properties for various biological
materials. We highlight here recent advances in amino acid N-carboxyanhydrides (NCAs) …

Highlights•PPIs that are dominated by a continuous epitope are amenable for inhibition.•A
significant share of PPIs contains such 'hot segments'.•Peptide-based inhibitors are obvious …

The relatively recent recognition of the major role played by antimicrobial peptides (AMPs) in
sustaining an effective host response to immune challenges was greatly influenced by …