Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies
IRA Mackenzie, M Neumann - Journal of neurochemistry, 2016 - Wiley Online Library
Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular
basis. The past decade has seen the discovery of several new FTD‐causing genetic …
basis. The past decade has seen the discovery of several new FTD‐causing genetic …
Clinical spectrum of amyotrophic lateral sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is primarily characterized by progressive loss of motor
neurons, although there is marked phenotypic heterogeneity between cases. Typical, or …
neurons, although there is marked phenotypic heterogeneity between cases. Typical, or …
Loss of C9 ORF 72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death
C Sellier, ML Campanari, C Julie Corbier… - The EMBO …, 2016 - embopress.org
An intronic expansion of GGGGCC repeats within the C9 ORF 72 gene is the most common
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (ALS‐FTD) …
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (ALS‐FTD) …
[HTML][HTML] Arizona study of aging and neurodegenerative disorders and brain and body donation program
Abstract The Brain and Body Donation Program (BBDP) at Banner Sun Health Research
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …
Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease
C Pottier, KF Bieniek, NC Finch, M van de Vorst… - Acta …, 2015 - Springer
Frontotemporal lobar degeneration with TAR DNA-binding protein 43 inclusions (FTLD-
TDP) is the most common pathology associated with frontotemporal dementia (FTD). Repeat …
TDP) is the most common pathology associated with frontotemporal dementia (FTD). Repeat …
C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis
C9orf72 hexanucleotide repeat expansions are the most common cause of familial
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) worldwide. The …
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) worldwide. The …
An update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations
The development of our understanding of frontotemporal dementia (FTD) has gathered pace
over the last 10 years. After taking a back seat to A lzheimer's disease for many years FTD …
over the last 10 years. After taking a back seat to A lzheimer's disease for many years FTD …
C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import
Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of
neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat …
neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat …
The clinical spectrum of sporadic and familial forms of frontotemporal dementia
IOC Woollacott, JD Rohrer - Journal of neurochemistry, 2016 - Wiley Online Library
The term frontotemporal dementia (FTD) describes a clinically, genetically and
pathologically diverse group of neurodegenerative disorders. Symptoms of FTD can present …
pathologically diverse group of neurodegenerative disorders. Symptoms of FTD can present …
Genetics of FTLD: overview and what else we can expect from genetic studies
C Pottier, TA Ravenscroft… - Journal of …, 2016 - Wiley Online Library
Frontotemporal lobar degeneration (FTLD) comprises a highly heterogeneous group of
disorders clinically associated with behavioral and personality changes, language …
disorders clinically associated with behavioral and personality changes, language …