PBRM1 loss reduces IFNγ-STAT1 activity and promotes resistance to immunotherapy and antiangiogen...

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Mammalian SWI/SNF complex genomic alterations and immune checkpoint blockade in solid tumors

S Abou Alaiwi, AH Nassar, W Xie, Z Bakouny… - Cancer immunology …, 2020 - AACR
Prior data have variably implicated the inactivation of the mammalian SWItch/Sucrose Non-
Fermentable (mSWI/SNF) complex with increased tumor sensitivity to immune checkpoint …
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