TGF-β in blood: a complex problem

DJ Grainger, DE Mosedale, JC Metcalfe - Cytokine & growth factor reviews, 2000 - Elsevier
The cytokine transforming growth factor-β (TGF-β) was initially purified from human platelets,
a rich source of this protein. In addition to platelets, TGF-β1 is also found in other blood …

TGF-β and atherosclerosis in man

DJ Grainger - Cardiovascular research, 2007 - academic.oup.com
The transforming growth factor type-β (TGF-β) superfamily of ligands, receptors, binding
proteins and ligand traps together plays a key role in the maintenance of normal blood …

Genetic control of the circulating concentration of transforming growth factor type β1

DJ Grainger, K Heathcote, M Chiano… - Human molecular …, 1999 - academic.oup.com
The concentration of transforming growth factor β (TGF-β) in plasma has been correlated
with the development of several diseases, including atherosclerosis and certain forms of …

Autologous concentrated platelet-rich plasma (cPRP) for local application in bone regeneration

A Dugrillon, H Eichler, S Kern, H Klüter - International journal of oral and …, 2002 - Elsevier
Platelets are rich in growth factors that may contribute to an accelerated tissue regeneration
process. The therapeutic osteogenic effect of local platelet administration probably depends …

The serum concentration of active transforming growth factor-β is severely depressed in advanced atherosclerosis

DJ Grainger, PR Kemp, JC Metcalfe, AC Liu… - Nature medicine, 1995 - nature.com
Recent evidence has led us to propose that transforming growth factor-β (TGF-β) is a key
inhibitor of atherosclerosis. We show here that a population of patients with advanced …

Systemic inflammatory parameters in patients with atherosclerosis of the coronary and peripheral arteries

M Erren, H Reinecke, R Junker, M Fobker… - … , and vascular biology, 1999 - Am Heart Assoc
Plasma concentration of markers of inflammation are increased in patients with
atherosclerosis. However, it is unclear whether the pattern and magnitude of this increase …

Release and activation of platelet latent TGF–β in blood clots during dissolution with plasmin

DJ Grainger, L Wakefield, HW Bethell, RW Farndale… - Nature medicine, 1995 - nature.com
Transforming growth factor β1 (TGF–β1) is a platelet–derived cytokine involved in both
normal wound healing and scarring. We show that human platelets contain two pools of …

Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer

C Li, B Guo, PB Wilson, A Stewart… - … Journal of Cancer, 2000 - Wiley Online Library
Abstract CD105 (endoglin), a receptor for transforming growth factor (TGF) β1 and β3 in
vascular endothelial cells, is highly up‐regulated in blood vessels of tissues where …

TGFβ1 and TGFβ2 concentrations are elevated in Parkinson's disease in ventricular cerebrospinal fluid

MP Vawter, O Dillon-Carter, WW Tourtellotte… - Experimental …, 1996 - Elsevier
Transforming growth factor (TGF) β plays a role in injury repair in sites surrounding brain
injury. The present study tested the hypothesis that TGFβ1 and TGFβ2 levels in the …

[PDF][PDF] Effects of platelet growth factors on human mesenchymal stem cells and human endothelial cells in vitro

O Kilian, I Flesch, S Wenisch, B Taborski… - European journal of …, 2004 - daignet.de
The aim of the present in vitro study has been to investigate the effects of a enriched platelet
derived growth factors on proliferation and migration of human endothelial and …