SARS-CoV-2 variants, vaccines, and host immunity

P Mistry, F Barmania, J Mellet, K Peta… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new beta coronavirus
that emerged at the end of 2019 in the Hubei province of China. SARS-CoV-2 causes …

Emerging SARS-CoV-2 variants of concern (VOCs): an impending global crisis

AYK Thye, JWF Law, P Pusparajah, V Letchumanan… - Biomedicines, 2021 - mdpi.com
The worldwide battle against the SARS-CoV-2 virus rages on, with millions infected and
many innocent lives lost. The causative organism, severe acute respiratory syndrome …

Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern

PR Wratil, M Stern, A Priller, A Willmann, G Almanzar… - Nature medicine, 2022 - nature.com
Infection-neutralizing antibody responses after severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection or coronavirus disease 2019 vaccination are an …

Genomics and epidemiology of the P. 1 SARS-CoV-2 lineage in Manaus, Brazil

NR Faria, TA Mellan, C Whittaker, IM Claro… - Science, 2021 - science.org
Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in
Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome …

COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P. 1 emergence

FG Naveca, V Nascimento, VC de Souza, AL Corado… - Nature medicine, 2021 - nature.com
The northern state of Amazonas is among the regions in Brazil most heavily affected by the
COVID-19 epidemic and has experienced two exponentially growing waves, in early and …

Effectiveness of the CoronaVac vaccine in older adults during a gamma variant associated epidemic of covid-19 in Brazil: test negative case-control study

OT Ranzani, MDT Hitchings, M Dorion, TL D'Agostini… - bmj, 2021 - bmj.com
Objective To estimate the effectiveness of the inactivated whole virus vaccine, CoronaVac
(Sinovac Biotech), against symptomatic covid-19 in the elderly population of São Paulo …

[HTML][HTML] Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

F Muecksch, Y Weisblum, CO Barnes, F Schmidt… - Immunity, 2021 - cell.com
Antibodies elicited by infection accumulate somatic mutations in germinal centers that can
increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related …

High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape

F Schmidt, Y Weisblum, M Rutkowska, D Poston… - Nature, 2021 - nature.com
The number and variability of the neutralizing epitopes targeted by polyclonal antibodies in
individuals who are SARS-CoV-2 convalescent and vaccinated are key determinants of …

Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species

R Wang, Q Zhang, J Ge, W Ren, R Zhang, J Lan, B Ju… - Immunity, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to
emerge during the global pandemic and may facilitate escape from current antibody …

Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants

P Han, C Su, Y Zhang, C Bai, A Zheng, C Qiao… - Nature …, 2021 - nature.com
Multiple SARS-CoV-2 variants of concern (VOCs) have been emerging and some have
been linked to an increase in case numbers globally. However, there is yet a lack of …