Chromatin remodelers: We are the drivers!!
Chromatin is a highly dynamic structure that imparts structural organization to the genome
and regulates the gene expression underneath. The decade long research in deciphering …
and regulates the gene expression underneath. The decade long research in deciphering …
Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes
AJ Morrison, X Shen - Nature reviews Molecular cell biology, 2009 - nature.com
Chromatin-modifying factors have essential roles in DNA processing pathways that dictate
cellular functions. The ability of chromatin modifiers, including the INO80 and SWR1 …
cellular functions. The ability of chromatin modifiers, including the INO80 and SWR1 …
[HTML][HTML] Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
T Ikura, VV Ogryzko, M Grigoriev, R Groisman, J Wang… - Cell, 2000 - cell.com
It is well known that histone acetylases are important chromatin modifiers and that they play
a central role in chromatin transcription. Here, we present evidence for novel roles of histone …
a central role in chromatin transcription. Here, we present evidence for novel roles of histone …
A chromatin remodelling complex involved in transcription and DNA processing
The packaging of the eukaryotic genome in chromatin presents barriers that restrict the
access of enzymes that process DNA,. To overcome these barriers, cells possess a number …
access of enzymes that process DNA,. To overcome these barriers, cells possess a number …
A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney
Polycystic kidney disease (PKD) is a common human genetic illness. It is characterized by
the formation of multiple kidney cysts that are thought to result from over-proliferation of …
the formation of multiple kidney cysts that are thought to result from over-proliferation of …
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme
C Jeronimo, D Forget, A Bouchard, Q Li, G Chua… - Molecular cell, 2007 - cell.com
We have performed a survey of soluble human protein complexes containing components of
the transcription and RNA processing machineries using protein affinity purification coupled …
the transcription and RNA processing machineries using protein affinity purification coupled …
14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking
MP Rubio, KM Geraghty, BHC Wong… - Biochemical …, 2004 - portlandpress.com
14-3-3-interacting proteins were isolated from extracts of proliferating HeLa cells using 14-3-
3 affinity chromatography, eluting with a phosphopeptide that competes with targets for 14-3 …
3 affinity chromatography, eluting with a phosphopeptide that competes with targets for 14-3 …
An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc
MA Wood, SB McMahon, MD Cole - Molecular cell, 2000 - cell.com
The c-Myc transactivation domain was used to affinity purify tightly associated nuclear
proteins. Two of these proteins were identified as TIP49 and a novel related protein called …
proteins. Two of these proteins were identified as TIP49 and a novel related protein called …
[HTML][HTML] Pontin52 and Reptin52 function as antagonistic regulators of β‐catenin signalling activity
In Wnt‐stimulated cells, β‐catenin becomes stabilized in the cytoplasm, enters the nucleus
and interacts with HMG box transcription factors of the lymphoid‐enhancing factor‐1 (LEF …
and interacts with HMG box transcription factors of the lymphoid‐enhancing factor‐1 (LEF …