Stress constitutes a state of threatened homeostasis triggered by intrinsic or extrinsic
adverse forces (stressors) and is counteracted by an intricate repertoire of physiologic and …

Enhanced susceptibility to inflammatory and autoimmune disease can be related to
impairments in HPA axis activity and associated hypocortisolism, or to glucocorticoid …

The brain is the key organ of stress reactivity, coping, and recovery processes. Within the
brain, a distributed neural circuitry determines what is threatening and thus stressful to the …

The capacity to predict future events permits a creature to detect, model, and manipulate the
causal structure of its interactions with its environment. Behavioral experiments suggest that …

Over 60 years ago, Selye1 recognized the paradox that the physiologic systems activated by
stress can not only protect and restore but also damage the body. What links these …

Adaptation in the face of potentially stressful challenges involves activation of neural,
neuroendocrine and neuroendocrine‐immune mechanisms. This has been called …

SES is consistently associated with health outcomes, yet little is known about the
psychosocial and behavioral mechanisms that might explain this association. Researchers …

Stress is known to suppress immune function and increase susceptibility to infections and
cancer. Paradoxically, stress is also known to exacerbate asthma, and allergic, autoimmune …

Brain Corticosteroid Receptor Balance in Health and Disease* | Endocrine Reviews | Oxford
Academic Skip to Main Content Advertisement Oxford Academic Journals Books Search Menu …

Celsus described four of the five cardinal signs of inflammation 2000 years ago, and
Eustachio discovered the adrenal glands almost 500 years ago, but not until 1936 did Selye …