Productive humoral responses require that naive B cells and their differentiated progeny
move among distinct micro-environments. In this review, we discuss how studies are …

The transcription factors Bach1 and Bach2, which belong to a basic region-leucine zipper
(bZip) family, repress target gene expression by forming heterodimers with small Maf …

Plasma cell responses are associated with anti-tumor immunity and favorable response to
immunotherapy. B cells can amplify anti-tumor immune responses through antibody …

Macrophages derived from monocyte precursors undergo specific polarization processes
which are influenced by the local tissue environment: classically activated (M1) …

Gene regulatory networks (GRNs) process important information in developmental biology
and biomedicine. A key knowledge gap concerns how their responses change over time …

Humoral immunity depends on efficient activation of B cells and their subsequent
differentiation into antibody-secreting cells (ASCs). The transcription factor NFκB cRel is …

Canalization, or robustness to genetic or environmental perturbations, is fundamental to
complex organisms. While there is strong evidence for canalization as an evolved property …

Quantitative systems pharmacology (QSP) is an emerging discipline that aims to discover
how drugs modulate the dynamics of biological components in molecular and cellular …

Human naïve B cells are notoriously difficult to differentiate into antibody‐secreting cells
(ASCs) in vitro while maintaining sufficient cell numbers to evaluate the differentiation …

Regulatory dependencies in molecular networks are the basis of dynamic behaviors
affecting the phenotypical landscape. With the advance of high throughput technologies, the …