Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …

As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …

Demyelination is a hallmark of multiple sclerosis, leukoencephalopathies, cerebral
vasculopathies, and several neurodegenerative diseases. The cuprizone mouse model is …

Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central
nervous system (CNS) due to an increase of abnormal peripherally auto-reactive T …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …

Although engulfment is a hallmark of microglia function, fully validated platforms that
facilitate high-throughput quantification of this process are lacking. Here, we present FEAST …

Inflammasomes are molecular scaffolds that are activated by damage-associated and
pathogen-associated molecular patterns and form a key element of innate immune …

Demyelination is a common pathological feature in a wide range of diseases, characterized
by the loss of myelin sheath and myelin-supporting oligodendrocytes. These losses lead to …

Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative
disease of the central nervous system (CNS). In people with MS, impaired remyelination and …

TMEM106B, a lysosomal transmembrane protein, has been closely associated with brain
health. Recently, an intriguing link between TMEM106B and brain inflammation has been …