Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects

E Kon, N Ad-El, I Hazan-Halevy… - Nature reviews clinical …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …

Nanoparticle surface functionalization: how to improve biocompatibility and cellular internalization

G Sanità, B Carrese, A Lamberti - Frontiers in molecular biosciences, 2020 - frontiersin.org
The use of nanoparticles (NP) in diagnosis and treatment of many human diseases,
including cancer, is of increasing interest. However, cytotoxic effects of NPs on cells and the …

An updated overview on metal nanoparticles toxicity

S Medici, M Peana, A Pelucelli, MA Zoroddu - Seminars in cancer biology, 2021 - Elsevier
Although thousands of different nanoparticles (NPs) have been identified and synthesized to
date, well-defined, consistent guidelines to control their exposure and evaluate their …

Multifunctional MnO2 nanoparticles for tumor microenvironment modulation and cancer therapy

G Yang, J Ji, Z Liu - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Tumor microenvironment (TME) is generally featured by low pH values, high glutathione
(GSH) concentrations, overproduced hydrogen peroxide (H2O2), and severe hypoxia …

Recent advances in near‐infrared‐II fluorescence imaging for deep‐tissue molecular analysis and cancer diagnosis

X Meng, X Pang, K Zhang, C Gong, J Yang, H Dong… - Small, 2022 - Wiley Online Library
Fluorescence imaging with high sensitivity and minimal invasiveness has received
tremendous attention, which can accomplish visualized monitoring and evaluation of cancer …

Thirty years of cancer nanomedicine: success, frustration, and hope

L Salvioni, MA Rizzuto, JA Bertolini, L Pandolfi… - Cancers, 2019 - mdpi.com
Starting with the enhanced permeability and retention (EPR) effect discovery, nanomedicine
has gained a crucial role in cancer treatment. The advances in the field have led to the …

Synthesis, principles, and properties of magnetite nanoparticles for in vivo imaging applications—A review

J Wallyn, N Anton, TF Vandamme - Pharmaceutics, 2019 - mdpi.com
The current nanotechnology era is marked by the emergence of various magnetic inorganic
nanometer-sized colloidal particles. These have been extensively applied and hold an …

Lipid nanoparticles for siRNA delivery in cancer treatment

SH El Moukhtari, E Garbayo, A Amundarain… - Journal of Controlled …, 2023 - Elsevier
RNA-based therapies, and siRNAs in particular, have attractive therapeutic potential for
cancer treatment due to their ability to silence genes that are imperative for tumor …

Bioimaging with upconversion nanoparticles

EM Mettenbrink, W Yang… - Advanced photonics …, 2022 - Wiley Online Library
Bioimaging enables the spatiotemporal visualization of biological processes at various
scales empowered by a range of different imaging modalities and contrast agents …

Exploring the application of micellar drug delivery systems in cancer nanomedicine

Q Wang, K Atluri, AK Tiwari, RJ Babu - Pharmaceuticals, 2023 - mdpi.com
Various formulations of polymeric micelles, tiny spherical structures made of polymeric
materials, are currently being investigated in preclinical and clinical settings for their …