Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance
and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and …

Congenital generalized lipodystrophy (CGL) is a heterogeneous autosomal recessive
disorder characterized by a near complete lack of adipose tissue from birth and, later in life …

Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism
of action is unclear. We genetically deleted the PTH/PTHrP receptor (PTH1R) in …

Lipid droplets (LDs) are storage organelles consisting of a neutral lipid core surrounded by a
phospholipid monolayer and a set of LD-specific proteins. Most LD components are …

Marrow adipose tissue (MAT) is functionally distinct from both white and brown adipose
tissue and can contribute to systemic and skeletal metabolism. MAT formation is a spatially …

Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) is caused by loss-of-function
mutations in SEIPIN, a protein implicated in both adipogenesis and lipid droplet expansion …

Type 2 diabetes mellitus (T2DM) is a well-recognized independent risk factor for heart
failure. T2DM is associated with altered cardiac energy metabolism, leading to ectopic lipid …

Seipin is necessary for both adipogenesis and lipid droplet (LD) organization in nonadipose
tissues; however, its molecular function is incompletely understood. Phenotypes in the …

Deficiency of the endoplasmic reticulum (ER) protein seipin results in generalized
lipodystrophy by incompletely understood mechanisms. Here, we report mitochondrial …

Lipodystrophy is a group of clinically heterogeneous, inherited or acquired, disorders
characterized by complete or partial absence of subcutaneous adipose tissue that may …