Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol
and corticosterone, act through the structurally similar mineralocorticoid (MR) and …

Estradiol is the most potent and ubiquitous member of a class of steroid hormones called
estrogens. Fetuses and newborns are exposed to estradiol derived from their mother, their …

We have investigated whether side chain-hydroxylated cholesterol species are important for
elimination of cholesterol from the brain. Plasma concentrations of 24-hydroxycholesterol …

Over the past decade, it has become clear that the brain is a steroidogenic organ. The
steroids synthesized by the brain and nervous system, given the name neurosteroids, have …

Progesterone has a broad spectrum of actions in the brain. Among these, the
neuroprotective effects are well documented. Progesterone neural effects are mediated by …

In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous
cholesterol has been doubted because of the inability to detect dehydroepiandrosterone …

Neurosteroids are synthetized in the central and peripheral nervous system, particularly but
not exclusively in myelinating glial cells, from cholesterol or steroidal precursors imported …

Glucocorticoids and mineralocorticoids are steroid hormones classically thought to be
secreted exclusively by the adrenal glands. However, recent evidence has shown that …