The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from
over-exuberant responses to pathogens and microbiota, while playing important roles in …

Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …

The capacity of IL-10 and Tregs in the inflammatory tumor microenvironment to impair
anticancer Th1 immunity makes them attractive targets for cancer immunotherapy. IL-10 and …

The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway is a
principal signaling pathway for the signal transduction of many pivotal cytokines involved in …

Bacterial pneumonia remains a significant burden worldwide. Although an inflammatory
response in the lung is required to fight the causative agent, persistent tissue-resident …

Breast cancer is the most commonly diagnosed type of cancer among the female population
worldwide. It is a disease with a high incidence and geographic distribution that negatively …

Purpose: The clinical effects of sunitinib on human myeloid-derived suppressor cell (MDSC)
subsets and correlation of the T-cell–mediated immune responses and clinical outcomes in …

Breast cancer (BC) is a frequently diagnosed cancer among women worldwide. Currently,
BC can be divided into different subgroups according to the presence of the following …

Tumor cell-derived factors, such as interleukin 10 (IL-10), polarize macrophages toward a
regulatory M2 phenotype, characterized by the expression of anti-inflammatory cytokines …

Signal transduction mechanism in the regulation of high mobility group box protein 1
(HMGB1) has not yet been well elucidated. Our data showed for the first time that Janus …