Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Despite the considerable progress in disease gene discovery, we are far from uncovering
the underlying cellular mechanisms of diseases since complex traits, even many Mendelian …

Background The identification of disease-related microRNAs is vital for understanding the
pathogenesis of diseases at the molecular level, and is critical for designing specific …

Accumulating experimental studies have demonstrated important associations between
alterations and dysregulations of lncRNAs and the development and progression of various …

Sequence comparison and alignment has had an enormous impact on our understanding of
evolution, biology and disease. Comparison and alignment of biological networks will …

Motivation: Understanding the association between genetic diseases and their causal genes
is an important problem concerning human health. With the recent influx of high-throughput …

Motivation: Widespread availability of low-cost, full genome sequencing will introduce new
challenges for bioinformatics. Results: This review outlines recent developments in …

Motivation Proteins are essential macromolecules of life and thus understanding their
function is of great importance. The number of functionally unclassified proteins is large …

Motivation: High-throughput methods for detecting molecular interactions have produced
large sets of biological network data with much more yet to come. Analogous to sequence …

Motivation: Biological network alignment aims to identify similar regions between networks
of different species. Existing methods compute node similarities to rapidly identify from …