Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis

CM Clouthier, JN Pelletier - Chemical Society Reviews, 2012 - pubs.rsc.org
This critical review presents an introduction to biocatalysis for synthetic chemists. Advances
in biocatalysis of the past 5 years illustrate the breadth of applications for these powerful and …

Enantioselective enzymatic desymmetrizations in organic synthesis

E García-Urdiales, I Alfonso, V Gotor - Chemical Reviews, 2005 - ACS Publications
During the recent past years, tremendous efforts have been made to establish
enantioselective routes for the preparation of enantiomerically pure compounds due to their …

Iminosugars past, present and future: medicines for tomorrow

G Horne, FX Wilson, J Tinsley, DH Williams… - Drug discovery today, 2011 - Elsevier
Iminosugars comprise the most attractive class of carbohydrate mimetics reported to date
and are ideally positioned to take advantage of our increasing understanding of …

Building bridges: Biocatalytic C–C-bond formation toward multifunctional products

NG Schmidt, E Eger, W Kroutil - ACS catalysis, 2016 - ACS Publications
Carbon–carbon bond formation is the key reaction for organic synthesis to construct the
carbon framework of organic molecules. The review gives a selection of biocatalytic C–C …

C− C bond-forming lyases in organic synthesis

M Brovetto, D Gamenara, P Saenz Mendez… - Chemical …, 2011 - ACS Publications
Lyases are enzymes that catalyze the bond construction and breaking by means other than
hydrolysis or redox reactions. Such enzymes are particular in the sense that they only …

Recent progress in stereoselective synthesis with aldolases

P Clapés, WD Fessner, GA Sprenger… - Current Opinion in …, 2010 - Elsevier
Aldol reactions constitute a powerful methodology for carbon–carbon bond formation in
synthetic organic chemistry. Biocatalysis by means of aldolases offers a unique …

Systematic design and in vitro validation of novel one-carbon assimilation pathways

X Yang, Q Yuan, H Luo, F Li, Y Mao, X Zhao, J Du… - Metabolic …, 2019 - Elsevier
The utilization of one-carbon (C 1) assimilation pathways to produce chemicals and fuels
from low-cost C 1 compounds could greatly reduce the substrate-related production costs …

Recent advances in the substrate selectivity of aldolases

V Hélaine, C Gastaldi, M Lemaire, P Clapés… - ACS …, 2021 - ACS Publications
Aldolases are powerful C–C bond-forming enzymes in biocatalysis because of their
unparalleled stereoselectivity, the ease with which reactions that do not require cofactor …

Biocatalytic Methods for C C Bond Formation

K Fesko, M Gruber‐Khadjawi - ChemCatChem, 2013 - Wiley Online Library
Carbon‐carbon bond formation is among the most challenging transformations in the
organic synthetic chemistry. Enzymes capable to perform this reaction are of great interest …

Current trends in asymmetric synthesis with aldolases

P Clapes, X Garrabou - Advanced Synthesis & Catalysis, 2011 - Wiley Online Library
Biocatalytic carbon‐carbon bond formation by means of aldolases offers an exceptionally
stereoselective and green tool for this strategic reaction in synthetic organic chemistry …