The human upper respiratory tract (URT) offers a variety of niches for microbial colonization.
Local microbial communities are shaped by the different characteristics of the specific …

Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

The cystic fibrosis (CF) lung microbiome has been studied in children and adults; however,
little is known about its relationship to early disease progression. To better understand the …

Objective To investigate age-associated changes in airway microbiome composition and
their relationships with lung function and arterial stiffness among genetically matched young …

Background Metastasis of upper airway microbiota may have significant implications in the
development of chronic lung disease. Here, we compare bacterial communities of matched …

Background The airways of healthy humans harbor a distinct microbial community.
Perturbations in the microbial community have been associated with disease, yet little is …

Background Inhaled corticosteroids (ICS) are the mainstay of asthma treatment, but
evidence suggests a link between ICS usage and increased rates of respiratory infections …

Abstract The 15th European Cystic Fibrosis Society (ECFS) Basic Science pre-conference
Symposium focused on the topic of the microbiome, asking the question “The lung and gut …

Pseudomonas aeruginosa (Pa) infection is a major cause of airway inflammation in
immunocompromised and cystic fibrosis (CF) patients. Mitogen-activated protein (MAP) and …

The lungs of people and companion animals are now recognized to harbor diverse, low
biomass bacterial communities. While these communities are difficult to characterize using …