Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

The actin filament is astonishingly well conserved across a diverse set of eukaryotic species.
It has essentially remained unchanged in the billion years that separate yeast, Arabidopsis …

Humans express 15 formins that play crucial roles in actin-based processes, including
cytokinesis, cell motility and mechanotransduction,. However, the lack of structures bound to …

Cellular viability requires tight regulation of actin cytoskeletal dynamics. Distinct families of
nucleation-promoting factors enable the rapid assembly of filament nuclei that elongate and …

Actin filaments generate mechanical forces that drive membrane movements during
trafficking, endocytosis and cell migration. Reciprocally, adaptations of actin networks to …

During angiogenesis in vivo, endothelial cells (ECs) at the tips of vascular sprouts actively
extend filopodia that are filled with bundles of linear actin filaments. To date, signaling …

Actin filaments (F-actin) are a key component of eukaryotic cells. Whether serving as a
scaffold for myosin or using their polymerization to push onto cellular components, their …

The dynamic actin cytoskeleton contributes to many critical biological processes by
providing the structural support underlying the morphology of most cells, facilitating …

Proteins targeting actin filament barbed ends play a pivotal role in motile processes. While
formins enhance filament assembly, capping protein (CP) blocks polymerization. On their …

During cytokinesis, the actin cytoskeleton is partitioned into two spatially distinct actin
isoform specific networks: a β-actin network that generates the equatorial contractile ring …