To use or not to use: an update on licit and illicit ketamine use

JH Li, B Vicknasingam, Y Cheung, W Zhou… - Substance abuse and …, 2011 - Taylor & Francis
Ketamine, a derivative of phencyclidine that was developed in the 1960s, is an anesthetic
and analgesic with hallucinogenic effects. In this paper, the pharmacological and …

Ketamine for the treatment of major depressive disorder and bipolar depression: a review of the literature

SE Grady, TA Marsh, A Tenhouse… - Mental Health …, 2017 - meridian.allenpress.com
Introduction: Over the past decade, ketamine has been studied for major depressive
disorder and bipolar depression. Ketamine is believed to exert its antidepressant properties …

Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial

AP Carlson, M Abbas, RL Alunday, F Qeadan… - Journal of …, 2018 - thejns.org
OBJECTIVE Retrospective clinical data and case studies support a therapeutic effect of
ketamine in suppression of spreading depolarization (SD) following brain injury. Preclinical …

First-line management of canine status epilepticus at home and in hospital-opportunities and limitations of the various administration routes of benzodiazepines

M Charalambous, HA Volk, L Van Ham… - BMC veterinary …, 2021 - Springer
Status epilepticus (SE) or prolonged epileptic seizure activity is a common neurological
emergency with a high mortality rate and, if left untreated, can lead to irreversible cerebral …

Comparison of intranasal versus intravenous midazolam for management of status epilepticus in dogs: A multi‐center randomized parallel group clinical study

M Charalambous, HA Volk, A Tipold… - Journal of veterinary …, 2019 - Wiley Online Library
Background The intranasal (IN) route for rapid drug administration in patients with brain
disorders, including status epilepticus, has been investigated. Status epilepticus is an …

Clinical evaluation of intranasal medetomidine–ketamine and medetomidine–S (+)-ketamine for induction of anaesthesia in rabbits in two centres with two different …

LC Weiland, K Kluge, APN Kutter, PW Kronen - Veterinary anaesthesia and …, 2017 - Elsevier
Objective The aim was to compare efficacy and side effects of induction with medetomidine–
ketamine or medetomidine–S (+)-ketamine by intranasal (IN) instillation in rabbits and to …

Pharmacokinetics of ketamine and three metabolites in Beagle dogs under sevoflurane vs. medetomidine comedication assessed by enantioselective capillary …

FA Sandbaumhüter, R Theurillat, RN Bektas… - … of Chromatography A, 2016 - Elsevier
Ketamine is often used for anesthesia in veterinary medicine. One possible comedication is
the sedative α 2-agonist medetomidine. Advantages of that combination are the …

S-ketamine versus racemic ketamine in dogs: their relative potency as induction agents

D Casoni, C Spadavecchia, C Adami - Veterinary anaesthesia and …, 2015 - Elsevier
Objective To determine the potency ratio between S-ketamine and racemic ketamine as
inductive agents for achieving tracheal intubation in dogs. Study design Prospective …

Clinical and pharmacokinetic evaluation of S-ketamine for intravenous general anaesthesia in horses undergoing field castration

D Casoni, C Spadavecchia, B Wampfler… - Acta Veterinaria …, 2015 - Springer
Background Intravenous anaesthetic drugs are the primary means for producing general
anaesthesia in equine practice. The ideal drug for intravenous anaesthesia has high …

Effects of medetomidine and its active enantiomer dexmedetomidine on N‐demethylation of ketamine in canines determined in vitro using enantioselective capillary …

FA Sandbaumhüter, R Theurillat… - Electrophoresis, 2015 - Wiley Online Library
Cytochrome P450 (CYP) enzymes catalyze the metabolism of both, the analgesic and
anesthetic drug ketamine and the α2‐adrenergic receptor‐agonist medetomidine that is …