Heat shock protein 27 (HSP27), induced by heat shock, environmental, and
pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone …

Glioblastoma (GBM) is the most common primary brain tumor, carrying a very poor
prognosis, with median overall survival at about 12 to 15 months despite surgical resection …

Alternative splicing is dysregulated in cancer and the reactivation of telomerase involves the
splicing of TERT transcripts to produce full-length (FL) TERT. Knowledge about the splicing …

Triple-negative breast cancer (TNBC) is a heterogeneous subtype with varying disease
outcomes. Tumor-infiltrating lymphocytes (TILs) are frequent in TNBC and have been shown …

Background Neuro-oncological ventral antigen 1 (NOVA1) is a neuron-specific RNA-binding
protein which regulates alternative splicing in the developing nervous system. Recent …

AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase
I and II clinical trials for the treatment of several cancers. However, the mechanisms by which …

Small heat shock proteins (sHSPs) are ubiquitous ATP-independent chaperones that play
essential roles in response to cellular stresses and protein homeostasis. Investigations of …

Circular RNAs (circRNAs) are class of non-coding RNAs formed by back-splicing events as
loops, and could be found in all types of organisms. They play important and diverse roles in …

Gliomas are malignant tumours of the human nervous system with different World Health
Organization (WHO) classifications, glioblastoma (GBM) with higher grade and are more …

Simple Summary Heat shock proteins (HSPs) play an important role in cellular metabolism
and therefore are highly expressed in malignant brain tumors. In the current review, the …