There is an urgency to find new treatment strategies that could prevent or delay the onset or
progression of AMD. Different classes of lipids and lipoproteins metabolism genes have …

Sphingolipids have emerged as bioactive lipids involved in the regulation of many
physiological and pathological processes. In the retina, they have been established to …

Background In spite of the important role of Apolipoprotein-M (ApoM) and Sphingosine-1-
Phosphate (S1P) played in atherosclerosis (AS), there was few related research reporting …

The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and
ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular …

Age-related macular degeneration (AMD) is a major leading cause of irreversible visual
impairment in the world with limited therapeutic interventions. Histological, biochemical …

Glaucoma is a complex neurodegenerative disease characterized by optic nerve damage
and apoptotic retinal ganglion cell (RGC) death, and is the leading cause of irreversible …

Although research on high-density lipoprotein (HDL) has historically focused on
atherosclerotic coronary disease, there exists untapped potential of HDL biology for the …

Vasculogenesis and angiogenesis play a crucial role in embryonic development.
Pathological neovascularization in ocular tissues can lead to vision-threatening vascular …

The sphingolipids ceramide (Cer), ceramide-1-phosphate (C1P), sphingosine (Sph), and
sphingosine-1-phosphate (S1P)) are key signaling molecules that regulate many patho …

Apolipoprotein M (ApoM) is a sphingosine 1-phosphate (S1P) carrier involved in the
regulation of S1P. Signaling pathways involving sphingosine kinases (SphKs) and S1P-S1P …