With the advent of novel bioorthogonal reactions and “click” chemistry, an increasing
number of strategies for the single labelling of proteins and oligonucleotides have emerged …

Background Emerging evidence indicates that plant miRNAs can present within human
circulating system through dietary intake and regulate human gene expression. Hence we …

Peptides are attractive drug candidates, but their utility is greatly limited by their inherent
susceptibility to proteolytic degradation and their inability to pass through the cell …

Oligonucleotide (ON) conjugates are increasingly important tools for various molecular
diagnostics, nanotechnological applications, and for the development of nucleic acid-based …

Determining atomic-level characteristics of molecules on two-dimensional surfaces is one of
the fundamental challenges in chemistry. High-resolution nuclear magnetic resonance …

An efficient method for the synthesis of multiply functionalized oligonucleotides (ONs)
utilizing a novel H-phosphonate alkyne-based linker for multiple functionalization (LMF) is …

Proteoglycans are important brush-like biomacromolecules, which serve a variety of
functions in the human body. While protein–bottlebrush hybrids are promising proteoglycan …

Long structured RNAs are useful biochemical and biological tools. They are usually
prepared enzymatically, but this precludes their site‐specific modification with functional …

Labeled RNAs are invaluable probes for investigation of RNA function and localization.
However, mRNA labeling remains challenging. Here, we developed an improved method for …

Functionalized oligoribonucleotides are essential tools in RNA chemical biology. Various
synthetic routes have been developed over recent years to conjugate functional groups to …