Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
Human engineered heart tissue models for disease modeling and drug discovery
The emergence of human induced pluripotent stem cells (hiPSCs) and efficient
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy
S Marchiano, K Nakamura, H Reinecke, L Neidig… - Cell Stem Cell, 2023 - cell.com
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer a promising cell-
based therapy for myocardial infarction. However, the presence of transitory ventricular …
based therapy for myocardial infarction. However, the presence of transitory ventricular …
3D co-culture of hiPSC-derived cardiomyocytes with cardiac fibroblasts improves tissue-like features of cardiac spheroids
P Beauchamp, CB Jackson, LC Ozhathil… - Frontiers in molecular …, 2020 - frontiersin.org
Purpose: Both cardiomyocytes and cardiac fibroblasts (CF) play essential roles in cardiac
development, function, and remodeling. Properties of 3D co-cultures are incompletely …
development, function, and remodeling. Properties of 3D co-cultures are incompletely …
Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly
used for personalised medicine and preclinical cardiotoxicity testing. Reports on hiPSC-CM …
used for personalised medicine and preclinical cardiotoxicity testing. Reports on hiPSC-CM …
Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the
potential to remuscularize infarcted hearts but their arrhythmogenicity remains an obstacle to …
potential to remuscularize infarcted hearts but their arrhythmogenicity remains an obstacle to …
Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and …
AJS Ribeiro, BD Guth, M Engwall, S Eldridge… - Frontiers in …, 2019 - frontiersin.org
Contractility of the myocardium engines the pumping function of the heart and is enabled by
the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on …
the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on …
Improved computational identification of drug response using optical measurements of human stem cell derived cardiomyocytes in microphysiological systems
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) hold great
potential for drug screening applications. However, their usefulness is limited by the relative …
potential for drug screening applications. However, their usefulness is limited by the relative …
Efficient differentiation of human pluripotent stem cells into cardiomyocytes on cell sorting thermoresponsive surface
The current differentiation process of human pluripotent stem cells (hPSCs) into
cardiomyocytes to enhance the purity of hPSC-derived cardiomyocytes requires some …
cardiomyocytes to enhance the purity of hPSC-derived cardiomyocytes requires some …
Contractility measurements for cardiotoxicity screening with ventricular myocardial slices of pigs
R Shi, M Reichardt, DJ Fiegle, LK Küpfer… - Cardiovascular …, 2023 - academic.oup.com
Aims Cardiotoxicity is one major reason why drugs do not enter or are withdrawn from the
market. Thus, approaches are required to predict cardiotoxicity with high specificity and …
market. Thus, approaches are required to predict cardiotoxicity with high specificity and …