Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …

Immune tolerance is critical to the avoidance of unwarranted immune responses against self
antigens. Multiple, non-redundant checkpoints are in place to prevent such potentially …

Mycobacterium tuberculosis infections cause 9 million new tuberculosis cases and 1.5
million deaths annually. To identify variants conferring risk of tuberculosis, we tested 28.3 …

The major histocompatibility complex (MHC) is located in chromosome 6p21 and contains
crucial regulators of immune response, including human leucocyte antigen (HLA) genes …

Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II)
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …

Our understanding of the mechanisms underlying HLA associations with inflammatory
arthritis continues to evolve. Disease associations have been refined, and interactions of …

Background: A complex interplay between genetic and environmental factors contributes to
disease etiology of most of the autoimmune disorders. Type 1 diabetes mellitus (T1DM) and …

Methods Six acknowledged experts in pediatric CD were chosen to provide a thorough
assessment of the data and to develop best practices in 6 topic areas: bone disease …

HLA-DQ heterodimers increase the susceptibility to autoimmune diseases, but their role in
hematopoietic cell transplantation is unknown. We tested the hypothesis that outcome after …

The concept of the immunogenicity of an antigen is frequently encountered in the context of
vaccine development, an area of intense interest currently due to the emergence or re …