The HTLV Tax protein is crucial for viral replication and for initiating malignant
transformation leading to the development of adult T-cell leukemia. Tax has been shown to …

T-cell transformation by the human T-cell leukemia virus type I (HTLV-I) involves
deregulation of cellular transcription factors, including members of the NF-κB family. In …

Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia
(ATL), a rapidly progressing, clonal malignancy of CD4+ T lymphocytes. Fewer than one in …

HTLV-1 is the etiological agent of adult T-cell leukemia (ATL), the neurological syndrome
TSP/HAM and certain other clinical disorders. The viral Tax protein is considered to play a …

The Tax oncoprotein of human T-cell leukemia virus type 1 (HTLV-1) induces leukemia in
transgenic mice and permanent T-cell growth in vitro. In transformed lymphocytes, it acts as …

Human T-cell lymphotropic/leukemia virus type 1 (HTLV-1) transforms human T cells in vitro,
and Tax, a potent transactivator of viral and cellular genes, plays a key role in cell …

Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent for adult T-cell
leukemia. HTLV-1 transforms lymphocytes, and there is increasing evidence that the virus …

The phosphatidylinositol-3-kinase (PI3K) and AKT (protein kinase B) signaling pathways
play an important role in regulating cell cycle progression and cell survival. In previous …

Retroviruses are associated with a variety of diseases, including immunological and
neurological disorders, and various forms of cancer. In humans, the Human T‐cell …

The tax gene product of human T-cell leukemia virus I induces aberrant expression of
various cellular genes, which contributes to transformation of host cells. Induction of many …