Adhesion protein structure, molecular affinities, and principles of cell-cell recognition
The ability of cells to organize into multicellular structures in precise patterns requires that
they" recognize" one another with high specificity. We discuss recent progress in …
they" recognize" one another with high specificity. We discuss recent progress in …
Protocadherins at the crossroad of signaling pathways
A Pancho, T Aerts, MD Mitsogiannis… - Frontiers in Molecular …, 2020 - frontiersin.org
Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …
Abnormal cell sorting underlies the unique X-linked inheritance of PCDH19 epilepsy
DT Pederick, KL Richards, SG Piltz, R Kumar… - Neuron, 2018 - cell.com
X-linked diseases typically exhibit more severe phenotypes in males than females. In
contrast, protocadherin 19 (PCDH19) mutations cause epilepsy in heterozygous females but …
contrast, protocadherin 19 (PCDH19) mutations cause epilepsy in heterozygous females but …
Regulation of neural circuit formation by protocadherins
SL Peek, KM Mah, JA Weiner - Cellular and molecular life sciences, 2017 - Springer
The protocadherins (Pcdhs), which make up the most diverse group within the cadherin
superfamily, were first discovered in the early 1990s. Data implicating the Pcdhs, including …
superfamily, were first discovered in the early 1990s. Data implicating the Pcdhs, including …
[HTML][HTML] X-chromosome regulation and sex differences in brain anatomy
A Raznahan, CM Disteche - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Humans show reproducible sex-differences in cognition and psychopathology that may be
contributed to by influences of gonadal sex-steroids and/or sex-chromosomes on regional …
contributed to by influences of gonadal sex-steroids and/or sex-chromosomes on regional …
PCDH19-related epilepsy syndrome: a comprehensive clinical review
D Samanta - Pediatric neurology, 2020 - Elsevier
PCDH19-related epilepsy is a distinct childhood-onset epilepsy syndrome characterized by
brief clusters of febrile and afebrile seizures with onset primarily before the age of three …
brief clusters of febrile and afebrile seizures with onset primarily before the age of three …
The female epilepsy protein PCDH19 is a new GABAAR-binding partner that regulates GABAergic transmission as well as migration and morphological maturation of …
S Bassani, AW Cwetsch, L Gerosa… - Human molecular …, 2018 - academic.oup.com
Abstract The PCDH19 gene (Xp22. 1) encodes the cell-adhesion protein protocadherin-19
(PCDH19) and is responsible for a neurodevelopmental pathology characterized by female …
(PCDH19) and is responsible for a neurodevelopmental pathology characterized by female …
Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression
Mutations in PCDH19 gene, which encodes protocadherin-19 (PCDH19), cause
Developmental and Epileptic Encephalopathy 9 (DEE9). Heterogeneous loss of PCDH19 …
Developmental and Epileptic Encephalopathy 9 (DEE9). Heterogeneous loss of PCDH19 …
Focal cortical malformations in children with early infantile epilepsy and PCDH19 mutations: case report
In this case report we assess the occurrence of cortical malformations in children with early
infantile epilepsy associated with variants of the gene protocadherin 19 (PCDH 19). We …
infantile epilepsy associated with variants of the gene protocadherin 19 (PCDH 19). We …
Proteomic analysis of the developing mammalian brain links PCDH19 to the Wnt/β-catenin signalling pathway
R de Nys, A Gardner, C van Eyk… - Molecular …, 2024 - nature.com
Clustering Epilepsy (CE) is a neurological disorder caused by pathogenic variants of the
Protocadherin 19 (PCDH19) gene. PCDH19 encodes a protein involved in cell adhesion …
Protocadherin 19 (PCDH19) gene. PCDH19 encodes a protein involved in cell adhesion …