Avian toll-like receptors

R Brownlie, B Allan - Cell and tissue research, 2011 - Springer
Abstract Analysis of the genomes of two distantly related bird species, chicken and zebra
finch (divergence of about 100 million years), indicate that there are ten avian toll-like …

Toll-like receptor evolution in birds: gene duplication, pseudogenization, and diversifying selection

H Velová, MW Gutowska-Ding, DW Burt… - … Biology and Evolution, 2018 - academic.oup.com
Toll-like receptors (TLRs) are key sensor molecules in vertebrates triggering initial phases of
immune responses to pathogens. The avian TLR family typically consists of ten receptors …

Molecular evolution of the toll-like receptor multigene family in birds

M Alcaide, SV Edwards - Molecular biology and evolution, 2011 - academic.oup.com
Toll-like receptors (TLR) are membrane-bound sensors of the innate immune system that
recognize invariant and distinctive molecular features of invading microbes and are also …

Episodic positive selection in the evolution of avian toll-like receptor innate immunity genes

CE Grueber, GP Wallis, IG Jamieson - PLoS One, 2014 - journals.plos.org
Toll-like receptors (TLRs) are a family of conserved pattern-recognition molecules
responsible for initiating innate and acquired immune responses. Because they play a key …

[PDF][PDF] The question waiting to be asked: Innate immunity receptors in the perspective of zoological research

M Vinkler, T Albrecht - Folia Zoologica, 2009 - academia.edu
In the last decade a great effort has been devoted in animal evolutionary ecology to
searching for interindividual and interspecific differences in anti-parasite resistance …

Genetic drift outweighs natural selection at toll‐like receptor (TLR) immunity loci in a re‐introduced population of a threatened species

CE Grueber, GP Wallis, IG Jamieson - Molecular Ecology, 2013 - Wiley Online Library
During population establishment, genetic drift can be the key driver of changes in genetic
diversity, particularly while the population is small. However, natural selection can also play …

LRRfinder: a web application for the identification of leucine-rich repeats and an integrative Toll-like receptor database

V Offord, TJ Coffey, D Werling - Developmental & Comparative Immunology, 2010 - Elsevier
Homology modelling is considered the most accurate technique for computational prediction
of protein structure. However, this technique comes with fundamental caveats of …

Adaptation and cryptic pseudogenization in penguin toll-like receptors

SR Fiddaman, M Vinkler, SG Spiro… - Molecular Biology …, 2022 - academic.oup.com
Penguins (Sphenisciformes) are an iconic order of flightless, diving seabirds distributed
across a large latitudinal range in the Southern Hemisphere. The extensive area over which …

Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)

A Fornůsková, M Vinkler, M Pagès, M Galan… - BMC evolutionary …, 2013 - Springer
Background In vertebrates, it has been repeatedly demonstrated that genes encoding
proteins involved in pathogen-recognition by adaptive immunity (eg MHC) are subject to …

Avian Toll-like receptor allelic diversity far exceeds human polymorphism: an insight from domestic chicken breeds

Z Świderská, A Šmídová, L Buchtová, A Bryjová… - Scientific Reports, 2018 - nature.com
Immune genes show remarkable levels of adaptive variation shaped by pathogen-mediated
selection. Compared to humans, however, population polymorphism in animals has been …