[HTML][HTML] NK cells and ILCs in tumor immunotherapy
Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
Transcriptional and epigenetic regulation of effector and memory CD8 T cell differentiation
Immune protection and lasting memory are accomplished through the generation of
phenotypically and functionally distinct CD8 T cell subsets. Understanding how these …
phenotypically and functionally distinct CD8 T cell subsets. Understanding how these …
Blocking TIM-3 in treatment-refractory advanced solid tumors: a phase Ia/b study of LY3321367 with or without an anti-PD-L1 antibody
Purpose: T-cell immunoglobulin and mucin-domain–containing molecule-3 (TIM-3) blunts
anticancer immunity and mediates resistance to programmed death 1 (PD-1) and PD ligand …
anticancer immunity and mediates resistance to programmed death 1 (PD-1) and PD ligand …
Not all immune checkpoints are created equal
A De Sousa Linhares, J Leitner… - Frontiers in …, 2018 - frontiersin.org
Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have
revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory …
revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory …
Tim-3 hampers tumor surveillance of liver-resident and conventional NK cells by disrupting PI3K signaling
S Tan, Y Xu, Z Wang, T Wang, X Du, X Song, X Guo… - Cancer research, 2020 - AACR
Natural killer (NK) cells are enriched within the liver. Apart from conventional NK (cNK) cells,
recent studies identified a liver-resident NK (LrNK) subset, which constitutes about half of …
recent studies identified a liver-resident NK (LrNK) subset, which constitutes about half of …
Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion
L Avery, J Filderman… - Proceedings of the …, 2018 - National Acad Sciences
Tim-3 is highly expressed on a subset of T cells during T cell exhaustion in settings of
chronic viral infection and tumors. Using lymphocytic choriomeningitis virus (LCMV) Clone …
chronic viral infection and tumors. Using lymphocytic choriomeningitis virus (LCMV) Clone …
The rise of NK cell checkpoints as promising therapeutic targets in cancer immunotherapy
H Sun, C Sun - Frontiers in immunology, 2019 - frontiersin.org
Checkpoint immunotherapy that targets inhibitory receptors of T cells, thereby reversing the
functional exhaustion of T cells, marks a breakthrough in anticancer therapy. The success of …
functional exhaustion of T cells, marks a breakthrough in anticancer therapy. The success of …
TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors
T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) expression has been
a trending topic in recent years due to its differential expression in a wide range of …
a trending topic in recent years due to its differential expression in a wide range of …
[HTML][HTML] Immune regulation by Tim-3
H Banerjee, LP Kane - F1000Research, 2018 - ncbi.nlm.nih.gov
T-cell immunoglobulin and mucin domain 3 (Tim-3) is a transmembrane protein that in both
mice and humans has been shown to possess various functions in a context-dependent …
mice and humans has been shown to possess various functions in a context-dependent …
CEACAM1 structure and function in immunity and its therapeutic implications
The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion
molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for …
molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for …